دورية أكاديمية
أعرض في EDS

Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.

التفاصيل البيبلوغرافية
العنوان: Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.
المؤلفون: Maschio-Lima T; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil. taiza.m.lima@unesp.br., Lemes TH; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil., Marques MDR; Department of Dermatological, Infectious, and Parasitic Diseases, School of Medicine São José Do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., Siqueira JPZ; Department of Dermatological, Infectious, and Parasitic Diseases, School of Medicine São José Do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil., de Almeida BG; Embrapa Instrumentation, São Paulo, Brazil., Caruso GR; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Von Zeska Kress MR; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., de Tarso da Costa P; Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil., Regasini LO; Laboratory of Antibiotics and Chemotherapy, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil., de Almeida MTG; Department of Dermatological, Infectious, and Parasitic Diseases, School of Medicine São José Do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brazil.
المصدر: International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2024 May 31. Date of Electronic Publication: 2024 May 31.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 9816585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1905 (Electronic) Linking ISSN: 11396709 NLM ISO Abbreviation: Int Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Switzerland AG : Springer Nature
Original Publication: Barcelona, Spain : Springer, c1998-
مستخلص: The scarce antifungal arsenal, changes in the susceptibility profile of fungal agents, and lack of adherence to treatment have contributed to the increase of cases of dermatomycoses. In this context, new antimicrobial substances have gained importance. Chalcones are precursors of the flavonoid family that have multiple biological activities, have high tolerability by humans, and easy synthesis. In this study, we evaluated the in vitro antifungal activity, alone and in combination with conventional antifungal drugs, of the VS02-4'ethyl chalcone-derived compound against dermatophytes and Candida spp. Susceptibility testing was carried out by broth microdilution. Experiments for determination of the target of the compound on the fungal cell, time-kill kinetics, and toxicity tests in Galleria mellonella model were also performed. Combinatory effects were evaluated by the checkerboard method. Results showed high activity of the compound VS02-4'ethyl against dermatophytes (MIC of 7.81-31.25 μg/ml). The compound targeted the cell membrane, and the time-kill test showed the compound continues to exert gradual activity after 5 days on dermatophytes, but no significant activity on Candida. Low toxicity was observed at 250 mg/kg. Excellent results were observed in the combinatory test, where VS02-4'ethyl showed synergistic interactions with itraconazole, fluconazole, terbinafine, and griseofulvin, against all isolates tested. Although further investigation is needed, these results revealed the great potential of chalcone-derived compounds against fungal infections for which treatments are long and laborious.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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فهرسة مساهمة: Keywords: Candida; Antifungal activity; Chalcones; Dermatomycoses; Dermatophytes; Synergistic interaction
تواريخ الأحداث: Date Created: 20240531 Latest Revision: 20240531
رمز التحديث: 20240531
DOI: 10.1007/s10123-024-00541-7
PMID: 38819732
قاعدة البيانات: MEDLINE
الوصف
تدمد:1618-1905
DOI:10.1007/s10123-024-00541-7