دورية أكاديمية
أعرض في EDS

5-HT receptors exert differential effects on seizure-induced respiratory arrest in DBA/1 mice.

التفاصيل البيبلوغرافية
العنوان: 5-HT receptors exert differential effects on seizure-induced respiratory arrest in DBA/1 mice.
المؤلفون: Pan Y; Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America., Tan Z; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.; Department of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, China., Guo J; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.; National Health Commission Key Laboratory of Birth Defect Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China., Feng HJ; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.
المصدر: PloS one [PLoS One] 2024 May 31; Vol. 19 (5), pp. e0304601. Date of Electronic Publication: 2024 May 31 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Receptors, Serotonin*/metabolism , Seizures*/metabolism , Mice, Inbred DBA*, Animals ; Mice ; Male ; Serotonin Receptor Agonists/pharmacology ; Sudden Unexpected Death in Epilepsy/etiology ; Disease Models, Animal
مستخلص: Both clinical and animal studies demonstrated that seizure-induced respiratory arrest (S-IRA) contributes importantly to sudden unexpected death in epilepsy (SUDEP). It has been shown that enhancing serotonin (5-HT) function relieves S-IRA in animal models of SUDEP, including DBA/1 mice. Direct activation of 5-HT3 and 5-HT4 receptors suppresses S-IRA in DBA/1 mice, indicating that these receptors are involved in S-IRA. However, it remains unknown if other subtypes of 5-HT receptors are implicated in S-IRA in DBA/1 mice. In this study, we investigated the action of an agonist of the 5-HT1A (8-OH-DPAT), 5-HT2A (TCB-2), 5-HT2B (BW723C86), 5-HT2C (MK-212), 5-HT6 (WAY-208466) and 5-HT7 (LP-211) receptor on S-IRA in DBA/1 mice. An agonist of the 5-HT receptor or a vehicle was intraperitoneally administered 30 min prior to acoustic simulation, and the effect of each drug/vehicle on the incidence of S-IRA was videotaped for offline analysis. We found that the incidence of S-IRA was significantly reduced by TCB-2 at 10 mg/kg (30%, n = 10; p < 0.01, Fisher's exact test) but was not altered by other agonists compared with the corresponding vehicle controls in DBA/1 mice. Our data demonstrate that 5-HT2A receptors are implicated in S-IRA, and 5-HT1A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors are not involved in S-IRA in DBA/1 mice.
Competing Interests: The authors declare no conflict of interest.
(Copyright: © 2024 Pan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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معلومات مُعتمدة: R01 NS112319 United States NS NINDS NIH HHS; R21 NS101311 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (Receptors, Serotonin)
0 (Serotonin Receptor Agonists)
تواريخ الأحداث: Date Created: 20240531 Date Completed: 20240531 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC11142501
DOI: 10.1371/journal.pone.0304601
PMID: 38820310
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0304601