دورية أكاديمية
أعرض في EDS

Efficacy and safety of peri-partum Esketamine for prevention of post-partum depression in women undergoing caesarian section: A meta-analysis and systematic review of randomized controlled trials.

التفاصيل البيبلوغرافية
العنوان: Efficacy and safety of peri-partum Esketamine for prevention of post-partum depression in women undergoing caesarian section: A meta-analysis and systematic review of randomized controlled trials.
المؤلفون: Nayyer MA; King Edward Medical University, Lahore, Pakistan. Electronic address: anasnayyer99@gmail.com., Khan SM; King Edward Medical University, Lahore, Pakistan. Electronic address: suchnamk@kemu.edu.pk., Umer M; King Edward Medical University, Lahore, Pakistan. Electronic address: uamir41@gmail.com., Imran H; King Edward Medical University, Lahore, Pakistan. Electronic address: haimimran@gmail.com., Khalid S; King Edward Medical University, Lahore, Pakistan. Electronic address: salmankhalid@kemu.edu.pk., Murtaza H; King Edward Medical University, Lahore, Pakistan. Electronic address: hassanmurtaza1394@gmail.com., Sarfraz A; King Edward Medical University, Lahore, Pakistan. Electronic address: arbabsarfraz12@gmail.com., Atiq N; King Edward Medical University, Lahore, Pakistan. Electronic address: nooratiqq@gmail.com., Rasool H; King Edward Medical University, Lahore, Pakistan. Electronic address: rasoolhamna@yahoo.com., Fatima M; Academic Department of Psychiatry and Behavioral Sciences, King Edward Medical University, Mayo Hospital, Lahore, Pakistan. Electronic address: madahfatima@gmail.com.
المصدر: Asian journal of psychiatry [Asian J Psychiatr] 2024 Jul; Vol. 97, pp. 104090. Date of Electronic Publication: 2024 May 21.
نوع المنشور: Systematic Review; Journal Article; Meta-Analysis; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101517820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-2026 (Electronic) Linking ISSN: 18762018 NLM ISO Abbreviation: Asian J Psychiatr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier
مواضيع طبية MeSH: Ketamine*/administration & dosage , Ketamine*/adverse effects , Depression, Postpartum*/prevention & control , Depression, Postpartum*/drug therapy , Randomized Controlled Trials as Topic* , Cesarean Section*/adverse effects, Humans ; Female ; Pregnancy
مستخلص: Postpartum depression (PPD) is a psychiatric condition affecting women post-childbirth. Medication combined with psychotherapy, is the current protocol for its treatment. A meta-analysis was conducted using RevMan 5.4 to explore the efficacy and safety of peri-partum administration of esketamine for preventing PPD. After searching several databases to retrieve the relevant RCTs, seven were included in this analysis, with dichotomous data presented as risk ratio and continuous data as mean difference. The study found a lower incidence of PPD in the esketamine group compared to the control group (RR= 0.37), with significant difference in EPDS scores between the two groups (MD= -1.23) in the first week postpartum. The esketamine group reported a lower prevalence of PPD 4-6 weeks postpartum (RR= 0.48), and no significant difference in EPDS scores after 4 weeks postpartum (MD = -0.10). The esketamine group had a significantly higher incidence of hallucination (RR= 13.85). Other adverse effects, such as dizziness (RR= 4.09), nausea (RR= 0.88), vomiting (RR=0.74), headache (RR=1.52), nightmares (RR=1.22), pruritus (RR=0.29), and drowsiness (RR=1.57) did not show significant differences between the two groups. The study found that esketamine, with manageable side effects, reduces the prevalence of post-partum depression (PPD) after one week as well as after four to six weeks. However, the findings are limited by the limited number of available RCTs, and future research should determine the ideal dosage, the most effective method of administration and the long-term safety profile of esketamine so that it may be considered as an adjunct therapy or a potential sole treatment option.
Competing Interests: Declaration of Competing Interest The authors report no relationships that could be construed as a conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Esketamine; Meta-analysis; Postnatal Depression; Postpartum Depression; Systematic review
المشرفين على المادة: 690G0D6V8H (Ketamine)
50LFG02TXD (Esketamine)
تواريخ الأحداث: Date Created: 20240531 Date Completed: 20240614 Latest Revision: 20240618
رمز التحديث: 20240619
DOI: 10.1016/j.ajp.2024.104090
PMID: 38820851
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-2026
DOI:10.1016/j.ajp.2024.104090