دورية أكاديمية
Deformable anthropomorphic pelvis phantom for dose accumulation verification.
| العنوان: | Deformable anthropomorphic pelvis phantom for dose accumulation verification. |
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| المؤلفون: | Wong YM; Division of Physics and Applied Physics, Nanyang Technological University, Singapore, Singapore., Koh CWY; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Ai3 Lab, National Cancer Centre Singapore, Singapore, Singapore., Lew KS; Division of Physics and Applied Physics, Nanyang Technological University, Singapore, Singapore.; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore., Chua CGA; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Ai3 Lab, National Cancer Centre Singapore, Singapore, Singapore., Yeap PL; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Department of Oncology, University of Cambridge, Cambridge, United Kingdom., Zhang ET; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore.; Singapore Centre for 3D Printing, Nanyang Technological University, Singapore, Singapore., Ong ALK; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Ai3 Lab, National Cancer Centre Singapore, Singapore, Singapore., Tuan JKL; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Ai3 Lab, National Cancer Centre Singapore, Singapore, Singapore., Ng BF; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, Singapore., Lew WS; Division of Physics and Applied Physics, Nanyang Technological University, Singapore, Singapore., Lee JCL; Division of Physics and Applied Physics, Nanyang Technological University, Singapore, Singapore.; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore., Tan HQ; Division of Physics and Applied Physics, Nanyang Technological University, Singapore, Singapore.; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Oncology Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore.; Ai3 Lab, National Cancer Centre Singapore, Singapore, Singapore. |
| المصدر: | Physics in medicine and biology [Phys Med Biol] 2024 Jun 11; Vol. 69 (12). Date of Electronic Publication: 2024 Jun 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : IOP Publishing |
| مواضيع طبية MeSH: | Phantoms, Imaging* , Pelvis*/diagnostic imaging, Humans ; Radiation Dosage ; Image Processing, Computer-Assisted/methods ; Tomography, X-Ray Computed ; Male ; Printing, Three-Dimensional |
| مستخلص: | Objective. The validation of deformable image registration (DIR) for contour propagation is often done using contour-based metrics. Meanwhile, dose accumulation requires evaluation of voxel mapping accuracy, which might not be accurately represented by contour-based metrics. By fabricating a deformable anthropomorphic pelvis phantom, we aim to (1) quantify the voxel mapping accuracy for various deformation scenarios, in high- and low-contrast regions, and (2) identify any correlation between dice similarity coefficient (DSC), a commonly used contour-based metric, and the voxel mapping accuracy for each organ. Approach . Four organs, i.e. pelvic bone, prostate, bladder and rectum (PBR), were 3D printed using PLA and a Polyjet digital material, and assembled. The latter three were implanted with glass bead and CT markers within or on their surfaces. Four deformation scenarios were simulated by varying the bladder and rectum volumes. For each scenario, nine DIRs with different parameters were performed on RayStation v10B. The voxel mapping accuracy was quantified by finding the discrepancy between true and mapped marker positions, termed the target registration error (TRE). Pearson correlation test was done between the DSC and mean TRE for each organ. Main results . For the first time, we fabricated a deformable phantom purely from 3D printing, which successfully reproduced realistic anatomical deformations. Overall, the voxel mapping accuracy dropped with increasing deformation magnitude, but improved when more organs were used to guide the DIR or limit the registration region. DSC was found to be a good indicator of voxel mapping accuracy for prostate and rectum, but a comparatively poorer one for bladder. DSC > 0.85/0.90 was established as the threshold of mean TRE ⩽ 0.3 cm for rectum/prostate. For bladder, extra metrics in addition to DSC should be considered. Significance . This work presented a 3D printed phantom, which enabled quantification of voxel mapping accuracy and evaluation of correlation between DSC and voxel mapping accuracy. (© 2024 Institute of Physics and Engineering in Medicine.) |
| فهرسة مساهمة: | Keywords: 3D printing; adaptive radiotherapy; deformable anthropomorphic phantom; deformable image registration; dice similarity coefficient; dose accumulation; target registration error |
| تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240611 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| DOI: | 10.1088/1361-6560/ad52e4 |
| PMID: | 38821109 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1361-6560 |
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| DOI: | 10.1088/1361-6560/ad52e4 |