دورية أكاديمية
Mu-opioid receptor activation in the habenula modulates synaptic transmission and depression-like behaviors.
| العنوان: | Mu-opioid receptor activation in the habenula modulates synaptic transmission and depression-like behaviors. |
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| المؤلفون: | Park H; Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea., Ryu H; Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea., Zhang S; Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea., Rhee J; Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea., Chung C; Department of Biological Sciences, Konkuk University, Seoul 05029, Republic of Korea. Electronic address: cchung@konkuk.ac.kr. |
| المصدر: | Neurobiology of disease [Neurobiol Dis] 2024 Aug; Vol. 198, pp. 106543. Date of Electronic Publication: 2024 May 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: San Diego, CA : Academic Press Original Publication: Oxford : Blackwell Science, c1994- |
| مواضيع طبية MeSH: | Habenula*/metabolism , Receptors, Opioid, mu*/metabolism , Helplessness, Learned* , Synaptic Transmission*/physiology , Depression*/metabolism, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological/metabolism ; Disease Models, Animal |
| مستخلص: | Opioid system dysregulation in response to stress is known to lead to psychiatric disorders including major depression. Among three different types of opioid receptors, the mu-type receptors (mORs) are highly expressed in the habenula complex, however, the action of mORs in this area and its interaction with stress exposure is largely unknown. Therefore, we investigated the roles of mORs in the habenula using male rats of an acute learned helplessness (aLH) model. First, we found that mOR activation decreased both excitatory and inhibitory synaptic transmission onto the lateral habenula (LHb). Intriguingly, this mOR-induced synaptic depression was reduced in an animal model of depression compared to that of controls. In naïve animals, we found an unexpected interaction between mORs and the endocannabinoid (eCB) signaling occurring in the LHb, which mediates presynaptic alteration occurring with mOR activation. However, we did not observe presynaptic alteration by mOR activation after stress exposure. Moreover, selective mOR activation in the habenula before, but not after, stress exposure effectively reduced helpless behaviors compared to aLH animals. Our observations are consistent with clinical reports suggesting the involvement of mOR signaling in depression, and additionally reveal a critical time window of mOR action in the habenula for ameliorating helplessness symptoms. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Depression; Endocannabinoid signaling; Helplessness; Lateral habenula; Muopioidreceptor |
| المشرفين على المادة: | 0 (Receptors, Opioid, mu) |
| تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240616 Latest Revision: 20240616 |
| رمز التحديث: | 20240617 |
| DOI: | 10.1016/j.nbd.2024.106543 |
| PMID: | 38821376 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-953X |
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| DOI: | 10.1016/j.nbd.2024.106543 |