دورية أكاديمية
Determination of the critical aggregation concentration in water of Gum Arabic functionalized with curcumin oxidation products by micro-scale thermophoresis approach.
| العنوان: | Determination of the critical aggregation concentration in water of Gum Arabic functionalized with curcumin oxidation products by micro-scale thermophoresis approach. |
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| المؤلفون: | Adam AA; Université de Lorraine, LIBio, F-54000 Nancy, France., Michaux F; Université de Lorraine, LIBio, F-54000 Nancy, France., Dos Santos Morais R; Université de Lorraine, LIBio, F-54000 Nancy, France., Seiler A; Université de Lorraine, LIBio, F-54000 Nancy, France., Muniglia L; Université de Lorraine, LIBio, F-54000 Nancy, France., Khanji AN; Université de Lorraine, LIBio, F-54000 Nancy, France., Jasniewski J; Université de Lorraine, LIBio, F-54000 Nancy, France. Electronic address: jordane.jasniewski@univ-lorraine.fr. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Jun; Vol. 271 (Pt 1), pp. 132510. Date of Electronic Publication: 2024 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Gum Arabic*/chemistry , Oxidation-Reduction* , Curcumin*/chemistry , Water*/chemistry, Micelles |
| مستخلص: | Gum Arabic underwent enzymatic modification with curcumin oxidation products, prompting self-assembly in water at lower concentrations than native gum Arabic, which was fully soluble. The resulting particles displayed a narrow size distribution, suggestive of a micellization mechanism akin to Critical Micellization Concentration (CMC) in surfactants or Critical Aggregation Concentration (CAC) in polymers. Accurately determining CAC is vital for utilizing polymers in molecule encapsulation, but precise measurement is challenging, requiring multiple techniques. Initially, CAC was probed via turbidity measurements, dynamic light scattering (DLS), and isothermal calorimetric titration (ITC), yielding a range of 0.0015 to 0.01 %. Micro-scale thermophoresis (MST) was then employed for the first time to define CAC more precisely, facilitated by the intrinsic fluorescence of modified gum Arabic. Using MST, CAC was pinpointed at 0.001 % (w/v), a novel approach. Furthermore, MST revealed a low EC50 value of 0.007 % (w/t) for self-assembly, signifying uniformity among GAC sub-units and assembly stability upon dilution. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Curcumin; Dynamic light scattering; Gum Arabic; Isothermal calorimetric titration; Self-assembly; micro-scale thermophoresis |
| المشرفين على المادة: | 9000-01-5 (Gum Arabic) IT942ZTH98 (Curcumin) 059QF0KO0R (Water) 0 (Micelles) |
| تواريخ الأحداث: | Date Created: 20240531 Date Completed: 20240619 Latest Revision: 20240619 |
| رمز التحديث: | 20240619 |
| DOI: | 10.1016/j.ijbiomac.2024.132510 |
| PMID: | 38821797 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2024.132510 |