دورية أكاديمية
أعرض في EDS

Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020.

التفاصيل البيبلوغرافية
العنوان: Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020.
المؤلفون: Rocha R; Institute of Hygiene and Tropical Medicine (IHMT), University Novaof Lisbon (UNL), Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal.; Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health, LA- REAL, IHMT, UNL, Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal.; University Hospital Center of São João, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal., Conceição C; Institute of Hygiene and Tropical Medicine (IHMT), University Novaof Lisbon (UNL), Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal.; Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health, LA- REAL, IHMT, UNL, Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal., Gonçalves L; Institute of Hygiene and Tropical Medicine (IHMT), University Novaof Lisbon (UNL), Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal.; Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health, LA- REAL, IHMT, UNL, Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal.; Faculty of Sciences, Centre of Statistics and its Application of the University of Lisbon, University of Lisbon, Campo Grande, Lisboa, 1749-016, Portugal.; Z-Stat4life, Cowork Space Baldaya, Baldaya Palace, Estrada de Benfica Nº 701ª, Lisboa, 1549-011, Portugal., Maia C; Institute of Hygiene and Tropical Medicine (IHMT), University Novaof Lisbon (UNL), Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal. CarlaMaia@ihmt.unl.pt.; Global Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health, LA- REAL, IHMT, UNL, Rua da Junqueira Nº100, Lisboa, 1349-008, Portugal. CarlaMaia@ihmt.unl.pt.
مؤلفون مشاركون: LeishPT group
المصدر: Infectious diseases of poverty [Infect Dis Poverty] 2024 Jun 01; Vol. 13 (1), pp. 41. Date of Electronic Publication: 2024 Jun 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101606645 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-9957 (Electronic) Linking ISSN: 20499957 NLM ISO Abbreviation: Infect Dis Poverty Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2012-
مواضيع طبية MeSH: Leishmaniasis, Visceral*/epidemiology , Leishmaniasis, Visceral*/diagnosis , Hospitals, Public*/statistics & numerical data, Humans ; Portugal/epidemiology ; Male ; Female ; Child ; Retrospective Studies ; Child, Preschool ; Adolescent ; Infant ; Adult ; Middle Aged ; Incidence ; Young Adult ; Leishmania infantum/isolation & purification ; Aged ; HIV Infections/epidemiology ; Infant, Newborn
مستخلص: Background: Leishmania infantum is endemic in the Mediterranean region, presenting mostly as visceral leishmaniasis (VL). In Portugal, reporting of VL cases to public health authorities is mandatory, but significant underreporting is likely. This study aimed to describe the epidemiological and clinical aspects of the VL cases diagnosed in hospitals of the Portuguese National Health Service (NHS), between 2010 and 2020.
Methods: Collaboration was requested to every hospital of the Portuguese NHS in Mainland Portugal. Cases were screened through a search of diagnostic discharge codes or, if not available, by a search of positive laboratory results for Leishmania infection. Sociodemographic and clinical data was retrieved from medical records. Simultaneously, the National Health authority was contacted to request access to data of notified cases of VL between 2010 and 2020. Descriptive, hypothesis testing and multiple binary logistic regression models were performed.
Results: A total of 221 VL cases were identified. A significant increase in estimated national incidence was seen in the years after 2016 (P = 0.030). VL was predominantly diagnosed in people living with HIV (PLWH) and in children (representing around 60% of the new cases), but the outcome was generally poorer in non-HIV patients with associated immunosuppression, with significantly lower rates of clinical improvement at 7 (P = 0.003) and 30 days (P = 0.008) after treatment. Atypical presentations, with gastrointestinal and/or respiratory involvement, were seen in 8.5% of VL cases. Hemophagocytic lymphohistiocytosis was diagnosed in 40.0% of children under 5 years of age. Only 49.7% of incident VL cases were reported. Simultaneous involvement of the skin was confirmed in 5.9% of patients.
Conclusions: VL presents a continuing threat in Portugal, especially to PLWH and children, and an increasing threat to other immunosuppressed groups. Recent increases in incidence should be closely monitored to allow prompt interventions. Programs to control the disease should focus on providing tools for earlier diagnosis and on reducing underreporting and promoting an integrated surveillance of human and animal disease. These data should be combined with asymptomatic infection and vector information, following a One Health approach.
(© 2024. The Author(s).)
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معلومات مُعتمدة: UI/BD/151067/2021 Fundação para a Ciência e a Tecnologia; UID/Multi/04413/2020 Fundação para a Ciência e a Tecnologia; LA/P/0117/2020 Fundação para a Ciência e a Tecnologia; UIDB/00006/2020 and UIDP/00006/2020 Fundação para a Ciência e a Tecnologia; 101057690 European Comission; 10038150 UK Research and Innovation; 10039289 UK Research and Innovation
فهرسة مساهمة: Investigator: AC Carvalho; A Maia; A Martins; A Carujo; A Maio; C Forra; C Melita; D Couto; D Fernandes; D Pereira; E Leal; H Sarmento; I Sousa; JP Gonçalves; J Marinho; J Vasconcelos; J Cunha; J Rodrigues; JM Silva; L Caley; L Malheiro; L Santos; M Garcia; M Prata; M Cunha; M Lima; MM Andrade; M Marques; M Alpalhão; M Silva; R Ferraz; R Soares; S Fernandes; S Llobet; S Cruz; T Guimarães; T Branco; T Robalo-Nunes; V Almeida
Keywords: Leishmania; Children; Leishmaniasis; People living with HIV; Portugal; Visceral
تواريخ الأحداث: Date Created: 20240601 Date Completed: 20240601 Latest Revision: 20240603
رمز التحديث: 20240603
مُعرف محوري في PubMed: PMC11143621
DOI: 10.1186/s40249-024-01204-5
PMID: 38822396
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9957
DOI:10.1186/s40249-024-01204-5