دورية أكاديمية
أعرض في EDS

Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal.

التفاصيل البيبلوغرافية
العنوان: Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal.
المؤلفون: Karim HT; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States., Lee S; Department of Psychiatry, University of Maryland, Baltimore, MD, United States., Gerlach A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Stinley M; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Berta R; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Mahbubani R; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Tudorascu DL; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, United States., Butters MA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States., Gross JJ; Department of Psychology, Stanford University, Stanford, CA, United States., Andreescu C; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: andrcx@upmc.edu.
المصدر: Neurobiology of aging [Neurobiol Aging] 2024 Sep; Vol. 141, pp. 55-65. Date of Electronic Publication: 2024 May 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
مواضيع طبية MeSH: Cognitive Dysfunction*/psychology , Cognitive Dysfunction*/diagnostic imaging , Cognitive Dysfunction*/pathology , Cognitive Dysfunction*/etiology , Hippocampus*/pathology , Hippocampus*/diagnostic imaging , Magnetic Resonance Imaging* , Anxiety*/psychology , Anxiety*/diagnostic imaging, Humans ; Male ; Female ; Aged ; Organ Size ; Cognition ; Cross-Sectional Studies ; Aged, 80 and over ; Alzheimer Disease/psychology ; Alzheimer Disease/pathology ; Alzheimer Disease/diagnostic imaging ; Atrophy ; Middle Aged ; Emotional Regulation/physiology
مستخلص: Studies have confirmed that anxiety, especially worry and rumination, are associated with increased risk for cognitive decline, including Alzheimer's disease and related dementias (ADRD). Hippocampal atrophy is a hallmark of ADRD. We investigated the association between hippocampus and its subfield volumes and late-life global anxiety, worry, and rumination, and emotion regulation strategies. We recruited 110 participants with varying worry severity who underwent magnetic resonance imaging and clinical interviews. We conducted cross-sectional regression analysis between each subfield and anxiety, worry, rumination, reappraisal, and suppression while adjusting for age, sex, race, education, cumulative illness burden, stress, neuroticism, and intracranial volume. We imputed missing data and corrected for multiple comparisons across regions. Greater worry was associated with smaller subiculum volume, whereas greater use of reappraisal was associated with larger subiculum and CA1 volume. Greater worry may be detrimental to the hippocampus and to subfields involved in early ADRD pathology. Use of reappraisal appears protective of hippocampal structure. Worry and reappraisal may be modifiable targets for ADRD prevention.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 MH108509 United States MH NIMH NIH HHS; R01 MH121619 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Anxiety; Hippocampal subfields; Hippocampus; Late-life; Reappraisal; Worry
تواريخ الأحداث: Date Created: 20240601 Date Completed: 20240713 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC11246796
DOI: 10.1016/j.neurobiolaging.2024.02.017
PMID: 38823204
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-1497
DOI:10.1016/j.neurobiolaging.2024.02.017