دورية أكاديمية
Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin.
| العنوان: | Enhanced ophthalmic bioavailability and stability of atropine sulfate via sustained release particles using polystyrene sulfonate resin. |
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| المؤلفون: | Li F; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Ye X; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Li M; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Nie Q; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China., Wang H; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Zhang G; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Dong L; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China., Wang C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China., Wu L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China., Liu H; Jiangsu University, Zhenjiang 212000, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China. Electronic address: hml19970522@163.com., Wang L; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China. Electronic address: 22914692@qq.com., Peng C; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. Electronic address: pengcan@ahtcm.edu.cn., Zhang J; College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China; Jiangsu Yunshi Pharmaceutical Technology Co. Ltd., Nantong 226133, China. Electronic address: jwzhang@simm.ac.cn. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2024 Jul 20; Vol. 660, pp. 124294. Date of Electronic Publication: 2024 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Biological Availability* , Delayed-Action Preparations*/pharmacokinetics , Polystyrenes*/chemistry , Polystyrenes*/pharmacokinetics , Ophthalmic Solutions*/pharmacokinetics , Ophthalmic Solutions*/administration & dosage , Atropine*/pharmacokinetics , Atropine*/administration & dosage , Atropine*/chemistry , Drug Stability*, Animals ; Rabbits ; Male ; Hypromellose Derivatives/chemistry ; Tears/metabolism ; Drug Liberation ; Aqueous Humor/metabolism ; Polysaccharides, Bacterial/chemistry ; Administration, Ophthalmic |
| مستخلص: | Atropine sulfate (ATS) eye drops at low concentrations constitute a limited selection for myopia treatment, with challenges such as low ophthalmic bioavailability and inadequate stability. This study proposes a novel strategy by synthesizing ophthalmic sodium polystyrene sulfonate resin (SPSR) characterized by a spherical shape and uniform size for cationic exchange with ATS. The formulation of ATS@SPSR suspension eye drops incorporates xanthan gum and hydroxypropyl methylcellulose (HPMC) as suspending agents. In vitro studies demonstrated that ATS@SPSR suspension eye drops exhibited sustained release characteristics, and tropic acid, its degradation product, remained undetected for 30 days at 40 °C. The ATS levels in the tear fluids and aqueous humor of New Zealand rabbits indicated a significant increase in mean residence time (MRT) and area under the drug concentration-time curve (AUC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Atropine sulfate; Bioavailability; Mean residence time; Myopia; Sodium polystyrene sulfonate resin; Stability; Sustained-release |
| المشرفين على المادة: | 0 (Delayed-Action Preparations) 0 (Polystyrenes) 0 (Ophthalmic Solutions) 7C0697DR9I (Atropine) 70KO0R01RY (polystyrene sulfonic acid) TTV12P4NEE (xanthan gum) 3NXW29V3WO (Hypromellose Derivatives) 0 (Polysaccharides, Bacterial) |
| تواريخ الأحداث: | Date Created: 20240601 Date Completed: 20240712 Latest Revision: 20240712 |
| رمز التحديث: | 20240713 |
| DOI: | 10.1016/j.ijpharm.2024.124294 |
| PMID: | 38823467 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2024.124294 |