دورية أكاديمية
Exploring novel protein-based biomarkers for advancing breast cancer diagnosis: A review.
| العنوان: | Exploring novel protein-based biomarkers for advancing breast cancer diagnosis: A review. |
|---|---|
| المؤلفون: | Vellan CJ; Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Islam T; Department of Surgery, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., De Silva S; Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo 03, Sri Lanka., Mohd Taib NA; Department of Surgery, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia., Prasanna G; Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo 03, Sri Lanka., Jayapalan JJ; Department of Molecular Medicine, Faculty of Medicine, Universiti Malaya, 50603, Kuala Lumpur, Malaysia; Universiti Malaya Centre for Proteomics Research (UMCPR), Universiti Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: jaime_jacklyn@um.edu.my. |
| المصدر: | Clinical biochemistry [Clin Biochem] 2024 Jul; Vol. 129, pp. 110776. Date of Electronic Publication: 2024 May 31. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0133660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2933 (Electronic) Linking ISSN: 00099120 NLM ISO Abbreviation: Clin Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: [Toronto] Canadian Society of Clinical Chemists. |
| مواضيع طبية MeSH: | Breast Neoplasms*/diagnosis , Breast Neoplasms*/metabolism , Biomarkers, Tumor*/metabolism , Proteomics*/methods, Humans ; Female ; Proteome/analysis ; Proteome/metabolism |
| مستخلص: | This review provides a contemporary examination of the evolving landscape of breast cancer (BC) diagnosis, focusing on the pivotal role of novel protein-based biomarkers. The overview begins by elucidating the multifaceted nature of BC, exploring its prevalence, subtypes, and clinical complexities. A critical emphasis is placed on the transformative impact of proteomics, dissecting the proteome to unravel the molecular intricacies of BC. Navigating through various sources of samples crucial for biomarker investigations, the review underscores the significance of robust sample processing methods and their validation in ensuring reliable outcomes. The central theme of the review revolves around the identification and evaluation of novel protein-based biomarkers. Cutting-edge discoveries are summarised, shedding light on emerging biomarkers poised for clinical application. Nevertheless, the review candidly addresses the challenges inherent in biomarker discovery, including issues of standardisation, reproducibility, and the complex heterogeneity of BC. The future direction section envisions innovative strategies and technologies to overcome existing challenges. In conclusion, the review summarises the current state of BC biomarker research, offering insights into the intricacies of proteomic investigations. As precision medicine gains momentum, the integration of novel protein-based biomarkers emerges as a promising avenue for enhancing the accuracy and efficacy of BC diagnosis. This review serves as a compass for researchers and clinicians navigating the evolving landscape of BC biomarker discovery, guiding them toward transformative advancements in diagnostic precision and personalised patient care. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biomarker discovery; Breast cancer; Diagnostic advances; Precision medicine; Proteomics |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (Proteome) |
| تواريخ الأحداث: | Date Created: 20240601 Date Completed: 20240627 Latest Revision: 20240627 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clinbiochem.2024.110776 |
| PMID: | 38823558 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-2933 |
|---|---|
| DOI: | 10.1016/j.clinbiochem.2024.110776 |