دورية أكاديمية
Use of privacy-preserving record linkage to examine the dispensing of pharmaceutical benefits scheme medicines to pregnant women in Western Australia.
العنوان: | Use of privacy-preserving record linkage to examine the dispensing of pharmaceutical benefits scheme medicines to pregnant women in Western Australia. |
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المؤلفون: | Kelty E; School of Population & Global Health, The University of Western Australia, Perth, Australia., Hansen M; Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Perth, Australia.; Telethon Kids Institute, Nedlands, Australia., Randall S; Centre for Data Linkage, Curtin University of Technology, Perth, Australia.; Institute for Health Transformation, Deakin University, Geelong, Australia., Gration D; Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Perth, Australia., Baynam G; Western Australian Register of Developmental Anomalies, King Edward Memorial Hospital, Perth, Australia.; Telethon Kids Institute, Nedlands, Australia., Preen DB; School of Population & Global Health, The University of Western Australia, Perth, Australia. |
المصدر: | Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2024 Jun; Vol. 33 (6), pp. e5845. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9208369 Publication Model: Print Cited Medium: Internet ISSN: 1099-1557 (Electronic) Linking ISSN: 10538569 NLM ISO Abbreviation: Pharmacoepidemiol Drug Saf Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Chichester, West Sussex : Wiley, 1992- |
مواضيع طبية MeSH: | Medical Record Linkage*, Humans ; Female ; Pregnancy ; Western Australia ; Retrospective Studies ; Adult ; Cross-Sectional Studies ; Young Adult ; Insurance, Pharmaceutical Services/statistics & numerical data ; Adolescent ; Infant, Newborn |
مستخلص: | Purpose: Medications are commonly used during pregnancy to manage pre-existing conditions and conditions that arise during pregnancy. However, not all medications are safe to use in pregnancy. This study utilized privacy-preserving record linkage (PPRL) to examine medications dispensed under the national Pharmaceutical Benefits Scheme (PBS) to pregnant women in Western Australia (WA) overall and by medication safety category. Methods: In this retrospective, cross-sectional, population-based study, state perinatal records (Midwives Notification Scheme) were linked with national PBS dispensing data using PPRL. Live and stillborn neonates born between 2012 and 2019 in WA were included. The proportion of pregnancies during which the mother was dispensed a PBS medication was calculated, overall and by medication safety category. Factors associated with PBS medication dispensing were examined using logistic regression. Results: PPRL linkage identified matching records for 97.4% of women with perinatal records. A total of 271 739 pregnancies were identified, with 158 585 (58.4%) pregnancies involving the dispensing of at least one PBS medication. Category A medications (those considered safe in pregnancy) were the most commonly dispensed (n = 119 126, 43.8%) followed by B3 (n = 51 135, 18.8%) and B1 (n = 42 388, 15.6%) medication (those with unknown safety). Over the study period, the dispensing of PBS medications in pregnancy increased (OR: 1.06, 95%CI: 1.06, 1.07). The strongest predictor of medication dispensing in pregnancy was pre-pregnancy dispensing (OR: 3.61, 95%CI: 3.54, 3.68). Other factors associated with medication use in pregnancy were smoking, older maternal age, obesity, and prior pregnancies. Conclusion: Privacy preserving record linkage provides a way to link cross-jurisdictional data while preserving patient confidentiality and data security. The dispensing of PBS medication in pregnancy was common and increased over time, with approximately 60% of women dispensed at least one medication during pregnancy. (© 2024 The Author(s). Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: drug dispensing; medicines; pharmacovigilance; pregnancy |
تواريخ الأحداث: | Date Created: 20240603 Date Completed: 20240603 Latest Revision: 20240603 |
رمز التحديث: | 20240603 |
DOI: | 10.1002/pds.5845 |
PMID: | 38825961 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1099-1557 |
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DOI: | 10.1002/pds.5845 |