دورية أكاديمية
Theanine Capture of Reactive Carbonyl Species in Humans after Consuming Theanine Capsules or Green Tea.
| العنوان: | Theanine Capture of Reactive Carbonyl Species in Humans after Consuming Theanine Capsules or Green Tea. |
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| المؤلفون: | Zhong Y; Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2# Xuelin Road, Nanjing 210023, P. R. China., Yang C; Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2# Xuelin Road, Nanjing 210023, P. R. China., Lu Y; Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2# Xuelin Road, Nanjing 210023, P. R. China., Lv L; Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2# Xuelin Road, Nanjing 210023, P. R. China. |
| المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jun 12; Vol. 72 (23), pp. 13240-13249. Date of Electronic Publication: 2024 Jun 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Tea*/chemistry , Glutamates*/metabolism , Glutamates*/analysis , Pyruvaldehyde*/metabolism , Pyruvaldehyde*/chemistry , Glyoxal*/metabolism , Glyoxal*/chemistry, Humans ; Male ; Adult ; Acrolein/metabolism ; Acrolein/chemistry ; Capsules/chemistry ; Camellia sinensis/chemistry ; Camellia sinensis/metabolism ; Female ; Young Adult ; Plant Extracts/chemistry ; Plant Extracts/metabolism ; Plant Extracts/administration & dosage ; Chromatography, High Pressure Liquid |
| مستخلص: | Acrolein (ACR), methylglyoxal (MGO), and glyoxal (GO) are a class of reactive carbonyl species (RCS), which play a crucial role in the pathogenesis of chronic and age-related diseases. Here, we explored a new RCS inhibitor (theanine, THE) and investigated its capture capacity on RCS in vivo by human experiments. After proving that theanine could efficiently capture ACR instead of MGO/GO by forming adducts under simulated physiological conditions, we further detected the ACR/MGO/GO adducts of theanine in the human urine samples after consumption of theanine capsules (200 and 400 mg) or green tea (4 cups, containing 200 mg of theanine) by using ultraperformance liquid chromatography-time-of-flight-high-resolution mass spectrometry. Quantitative assays revealed that THE-ACR, THE-2ACR-1, THE-MGO, and THE-GO were formed in a dose-dependent manner in the theanine capsule groups; the maximum value of the adducts of theanine was also tested. Furthermore, besides the RCS adducts of theanine, the RCS adducts of catechins could also be detected in the drinking tea group. Whereas, metabolite profile analysis showed that theanine could better capture RCS produced in the renal metabolic pathway than catechins. Our findings indicated that theanine could reduce RCS in the body in two ways: as a pure component or contained in tea leaves. |
| فهرسة مساهمة: | Keywords: acrolein; glyoxal; methylglyoxal; reactive carbonyl species; tea; theanine |
| المشرفين على المادة: | 8021PR16QO (theanine) 0 (Tea) 0 (Glutamates) 722KLD7415 (Pyruvaldehyde) 50NP6JJ975 (Glyoxal) 7864XYD3JJ (Acrolein) 0 (Capsules) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240603 Date Completed: 20240612 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1021/acs.jafc.4c02481 |
| PMID: | 38825967 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.4c02481 |