دورية أكاديمية
Rationally Minimizing Natural Product Libraries Using Mass Spectrometry.
العنوان: | Rationally Minimizing Natural Product Libraries Using Mass Spectrometry. |
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المؤلفون: | Ness M; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.; Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, 92182, United States., Peramuna T; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Wendt KL; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Collins JE; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., King JB; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Paes R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Okeke C; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Miller CR; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Chakrabarti D; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Cichewicz RH; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., McCall LI; Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, 92182, United States. |
المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2024 May 26. Date of Electronic Publication: 2024 May 26. |
نوع المنشور: | Journal Article; Preprint |
اللغة: | English |
بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
مستخلص: | Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings. |
References: | Nat Biotechnol. 2012 Oct;30(10):918-20. (PMID: 23051804) Gigascience. 2022 Dec 28;12:. (PMID: 36649739) Molecules. 2022 Dec 24;28(1):. (PMID: 36615351) J Nat Prod. 2019 Aug 23;82(8):2167-2173. (PMID: 31335140) J Nat Prod. 2012 Oct 26;75(10):1819-23. (PMID: 23046341) Sci Adv. 2020 Jul 22;6(30):eaaz2015. (PMID: 32766448) Science. 1976 Aug 20;193(4254):673-5. (PMID: 781840) J Nat Prod. 2016 Mar 25;79(3):629-61. (PMID: 26852623) J Med Chem. 2016 Apr 14;59(7):3183-203. (PMID: 26967507) ACS Infect Dis. 2019 Aug 9;5(8):1456-1470. (PMID: 31265248) Angew Chem Int Ed Engl. 2014 Jan 13;53(3):804-9. (PMID: 24285637) Ther Drug Monit. 2005 Dec;27(6):747-51. (PMID: 16404815) J Cheminform. 2015 Jul 07;7:33. (PMID: 26150895) Cell Chem Biol. 2024 Feb 15;31(2):312-325.e9. (PMID: 37995692) J Nat Prod. 2022 Apr 22;85(4):1079-1088. (PMID: 35416663) J Nat Prod. 2018 Apr 27;81(4):758-767. (PMID: 29498278) J Nat Prod. 2017 Mar 24;80(3):588-597. (PMID: 28335604) mSystems. 2021 Oct 26;6(5):e0064421. (PMID: 34698546) Nat Biotechnol. 2016 Aug 9;34(8):828-837. (PMID: 27504778) Br J Pharmacol. 2011 Mar;162(6):1239-49. (PMID: 21091654) Nat Prod Rep. 2021 Mar 4;38(2):292-300. (PMID: 32706349) Molecules. 2022 Mar 22;27(7):. (PMID: 35408437) Pharmaceuticals (Basel). 2023 Aug 15;16(8):. (PMID: 37631072) |
معلومات مُعتمدة: | R01 AI154777 United States AI NIAID NIH HHS; R01 GM145649 United States GM NIGMS NIH HHS |
تواريخ الأحداث: | Date Created: 20240603 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC11142144 |
DOI: | 10.1101/2024.05.22.595232 |
PMID: | 38826280 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2692-8205 |
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DOI: | 10.1101/2024.05.22.595232 |