دورية أكاديمية
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Rationally Minimizing Natural Product Libraries Using Mass Spectrometry.

التفاصيل البيبلوغرافية
العنوان: Rationally Minimizing Natural Product Libraries Using Mass Spectrometry.
المؤلفون: Ness M; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.; Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, 92182, United States., Peramuna T; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Wendt KL; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Collins JE; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., King JB; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Paes R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Okeke C; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Miller CR; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Chakrabarti D; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, 32826, United States., Cichewicz RH; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., McCall LI; Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, 92182, United States.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 26. Date of Electronic Publication: 2024 May 26.
نوع المنشور: Journal Article; Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Natural product libraries are crucial to drug development, but large libraries drastically increase the time and cost during initial high throughput screens. Here, we developed a method that leverages liquid chromatography-tandem mass spectrometry spectral similarity to dramatically reduce library size, with minimal bioactive loss. This method offers a broadly applicable strategy for accelerated drug discovery with cost reductions, which enable implementation in resource-limited settings.
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معلومات مُعتمدة: R01 AI154777 United States AI NIAID NIH HHS; R01 GM145649 United States GM NIGMS NIH HHS
تواريخ الأحداث: Date Created: 20240603 Latest Revision: 20240714
رمز التحديث: 20240714
مُعرف محوري في PubMed: PMC11142144
DOI: 10.1101/2024.05.22.595232
PMID: 38826280
قاعدة البيانات: MEDLINE
الوصف
تدمد:2692-8205
DOI:10.1101/2024.05.22.595232