دورية أكاديمية

Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis.

التفاصيل البيبلوغرافية
العنوان: Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis.
المؤلفون: Wareing N; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA.; Division of Rheumatology, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Mills TW; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA., Collum S; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA., Wu M; Division of Rheumatology, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Revercomb L; Rice University, Houston TX, USA., Girard R; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA., Lyons M; Division of Rheumatology, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Skaug B; Division of Rheumatology, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Bi W; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA., Ali MA; D Bradley McWilliams School of Biomedical Informatics, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Koochak H; Department of Pediatrics, McGovern Medical School, UTHealth Houston, Houston TX, USA., Flores AR; Department of Pediatrics, McGovern Medical School, UTHealth Houston, Houston TX, USA., Yang Y; D Bradley McWilliams School of Biomedical Informatics, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Zheng WJ; D Bradley McWilliams School of Biomedical Informatics, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Swindell WR; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Assassi S; Division of Rheumatology, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA., Karmouty-Quintana H; Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth Houston), TX, USA.; Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine, McGovern Medical School, UTHealth Houston, Houston TX, USA.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 19. Date of Electronic Publication: 2024 Jul 19.
نوع المنشور: Journal Article; Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Dermal fibrosis is a cardinal feature of systemic sclerosis (SSc) for which there are limited treatment strategies. This is in part due to our fragmented understanding of how dermal white adipose tissue (DWAT) contributes to skin fibrosis. We identified elevated sine oculis homeobox homolog 1 (SIX1) expression in SSc skin samples from the GENISOS and PRESS cohorts, the expression of which correlated with adipose-associated genes and molecular pathways. SIX1 localization studies identified increased signals in the DWAT area in SSc and in experimental models of skin fibrosis. Global and adipocyte specific Six1 deletion abrogated end-stage fibrotic gene expression and dermal adipocyte shrinkage induced by SQ bleomycin treatment. Further studies revealed a link between elevated SIX1 and increased expression of SERPINE1 and its protein PAI-1 which are known pro-fibrotic mediators. However, SIX1 deletion did not appear to affect cellular trans differentiation. Taken together these results point at SIX1 as a potential target for dermal fibrosis in SSc.
معلومات مُعتمدة: UL1 TR003167 United States TR NCATS NIH HHS; R56 AG076144 United States AG NIA NIH HHS; R01 HL157100 United States HL NHLBI NIH HHS; R01 HL168128 United States HL NHLBI NIH HHS; K08 AR081402 United States AR NIAMS NIH HHS; R01 AR073284 United States AR NIAMS NIH HHS; R01 HL138510 United States HL NHLBI NIH HHS; R01 AR081280 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: adipose; fibrosis; scleroderma; systemic sclerosis
تواريخ الأحداث: Date Created: 20240603 Latest Revision: 20240828
رمز التحديث: 20240828
مُعرف محوري في PubMed: PMC11142148
DOI: 10.1101/2024.05.22.595271
PMID: 38826482
قاعدة البيانات: MEDLINE
الوصف
تدمد:2692-8205
DOI:10.1101/2024.05.22.595271