دورية أكاديمية
أعرض في EDS

Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis.
المؤلفون: Belal MM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Khalefa BB; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Ain shams University, Cairo, Egypt., Rabea EM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Aly Yassin MN; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Helwan University, Cairo, Egypt., Bashir MN; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Abd El-Hameed MM; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Zagazig University, Ash Sharqia, Egypt., Elkoumi O; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Suez University, Suez, Egypt., Saad SM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Saad LM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Elkasaby MH; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
المصدر: Future science OA [Future Sci OA] 2024 May 14; Vol. 10 (1), pp. FSO956. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Future Science Group Country of Publication: England NLM ID: 101665030 Publication Model: eCollection Cited Medium: Print ISSN: 2056-5623 (Print) Linking ISSN: 20565623 NLM ISO Abbreviation: Future Sci OA Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Future Science Group, [2015]-
مستخلص: Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. Results & conclusion: The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications.
Competing Interests: The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
(© 2024 The Authors.)
References: Ann Intern Med. 1976 Jun;84(6):633-8. (PMID: 820228)
Diabetes Care. 1980 Jan-Feb;3(1):15-20. (PMID: 6773725)
J Pediatr. 2005 May;146(5):688-92. (PMID: 15870676)
Arch Dis Child. 2003 Feb;88(2):170-3. (PMID: 12538330)
Indian Pediatr. 2021 Jul 15;58(7):617-623. (PMID: 33612484)
Diabetologia. 2006 Sep;49(9):2002-9. (PMID: 16847700)
JAMA Pediatr. 2014 Nov;168(11):999-1005. (PMID: 25264948)
Arch Dis Child. 1999 Oct;81(4):318-23. (PMID: 10490436)
Diabetes Metab Syndr Obes. 2019 Nov 12;12:2355-2361. (PMID: 31814748)
Syst Rev. 2016 Dec 5;5(1):210. (PMID: 27919275)
Arq Bras Endocrinol Metabol. 2011 Jun;55(4):288-90. (PMID: 21779633)
Pediatr Crit Care Med. 2012 Jul;13(4):e227-33. (PMID: 22610448)
Pediatrics. 2004 Feb;113(2):e133-40. (PMID: 14754983)
Arch Intern Med. 1999 Feb 22;159(4):333-6. (PMID: 10030305)
Diabetes Care. 2002 Sep;25(9):1591-6. (PMID: 12196432)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
CMAJ. 2018 Apr 9;190(14):E416-E421. (PMID: 29632036)
Pediatr Diabetes. 2003 Jun;4(2):77-81. (PMID: 14655263)
Pediatr Crit Care Med. 2011 Mar;12(2):137-40. (PMID: 20473242)
World J Diabetes. 2015 Feb 15;6(1):167-74. (PMID: 25685287)
Indian J Endocrinol Metab. 2015 Apr;19(Suppl 1):S55-7. (PMID: 25941653)
Am J Ther. 2007 May-Jun;14(3):265-8. (PMID: 17515702)
Diabetes Metab Rev. 1989 Jun;5(4):337-63. (PMID: 2498055)
Diabetes Metab Syndr Obes. 2021 Dec 19;14:4819-4827. (PMID: 34984014)
Diabetes. 1982 Sep;31(9):795-801. (PMID: 6761214)
Diabetes. 1988 Nov;37(11):1470-7. (PMID: 3141236)
Curr Opin Pediatr. 2002 Jun;14(3):287-91. (PMID: 12011666)
Lancet. 1975 Dec 20;2(7947):1221-4. (PMID: 53719)
J Pediatr. 2007 May;150(5):467-73. (PMID: 17452217)
Indian J Endocrinol Metab. 2022 Mar-Apr;26(2):173-179. (PMID: 35873943)
Pediatr Diabetes. 2010 Feb;11(1):12-7. (PMID: 19602154)
Pediatr Diabetes. 2022 Nov;23(7):835-856. (PMID: 36250645)
فهرسة مساهمة: Keywords: DKA; diabetic ketoacidosis; insulin; low dose; pediatrics; standard dose
Local Abstract: [plain-language-summary] When kids with type 1 Diabetes (T1DM) face a serious complication called Diabetic Ketoacidosis (DKA), it becomes a life-threatening situation. This condition, responsible for significant mortality, involves high blood sugar, ketone buildup and acidity. Our study delves into a critical aspect of DKA treatment-finding the right insulin dose. By pooling the studies on this point, we discovered that using a lower insulin dose is just as effective as the standard dose in managing DKA in children, with fewer complications. This insight is crucial for improving the care and outcomes for young patients dealing with this challenging condition.
تواريخ الأحداث: Date Created: 20240603 Latest Revision: 20240604
رمز التحديث: 20240604
مُعرف محوري في PubMed: PMC11140676
DOI: 10.2144/fsoa-2023-0137
PMID: 38827803
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-5623
DOI:10.2144/fsoa-2023-0137