دورية أكاديمية
Navigating Complexities: Vitamin D, Skin Pigmentation, and Race.
| العنوان: | Navigating Complexities: Vitamin D, Skin Pigmentation, and Race. |
|---|---|
| المؤلفون: | Singh Ospina N; Division of Endocrinology, University of Florida, Gainesville, FL 32610, USA., Diaz-Thomas A; Division of Pediatric Endocrinology, Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN 38163, USA., McDonnell ME; Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Demay MB; Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Pittas AG; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Tufts Medical Center, Boston, MA 02111, USA., York E; Endocrine Society, Washington, DC 20036, USA., Corrigan MD; Endocrine Society, Washington, DC 20036, USA., Lash RW; Endocrine Society, Washington, DC 20036, USA., Brito JP; Division of Diabetes, Endocrinology, Metabolism, and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Murad MH; Mayo Clinic, Evidence-Based Practice Center, Rochester, MN 55905, USA., McCartney CR; Division of Endocrinology and Metabolism, Department of Medicine, West Virginia University, Morgantown, WV 26506, USA. |
| المصدر: | The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jul 12; Vol. 109 (8), pp. 1955-1960. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Springfield, Ill. : Charles C. Thomas |
| مواضيع طبية MeSH: | Skin Pigmentation*/physiology , Vitamin D*/metabolism , Vitamin D*/analogs & derivatives, Humans ; Vitamin D Deficiency ; Practice Guidelines as Topic ; Racial Groups |
| مستخلص: | Vitamin D plays a critical role in many physiological functions, including calcium metabolism and musculoskeletal health. This commentary aims to explore the intricate relationships among skin complexion, race, and 25-hydroxyvitamin D (25[OH]D) levels, focusing on challenges the Endocrine Society encountered during clinical practice guideline development. Given that increased melanin content reduces 25(OH)D production in the skin in response to UV light, the guideline development panel addressed the potential role for 25(OH)D screening in individuals with dark skin complexion. The panel discovered that no randomized clinical trials have directly assessed vitamin D related patient-important outcomes based on participants' skin pigmentation, although race and ethnicity often served as presumed proxies for skin pigmentation in the literature. In their deliberations, guideline panel members and selected Endocrine Society leaders underscored the critical need to distinguish between skin pigmentation as a biological variable and race and ethnicity as socially determined constructs. This differentiation is vital to maximize scientific rigor and, thus, the validity of resulting recommendations. Lessons learned from the guideline development process emphasize the necessity of clarity when incorporating race and ethnicity into clinical guidelines. Such clarity is an essential step toward improving health outcomes and ensuring equitable healthcare practices. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.) |
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| معلومات مُعتمدة: | K08 CA248972 United States CA NCI NIH HHS; K08CA248972 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: GRADE approach; ethnicity; race; skin pigmentation; vitamin D; vitamin D deficiency |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) |
| تواريخ الأحداث: | Date Created: 20240603 Date Completed: 20240712 Latest Revision: 20240715 |
| رمز التحديث: | 20240716 |
| مُعرف محوري في PubMed: | PMC11244154 |
| DOI: | 10.1210/clinem/dgae314 |
| PMID: | 38828960 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7197 |
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| DOI: | 10.1210/clinem/dgae314 |