دورية أكاديمية
The role of chaperone-mediated autophagy in drug resistance.
| العنوان: | The role of chaperone-mediated autophagy in drug resistance. |
|---|---|
| المؤلفون: | Teixeira ABDS; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Ramalho MCC; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Souza I; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Andrade IAM; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Osawa IYA; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Guedes CB; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Oliveira BS; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Souza Filho CHD; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Silva TLD; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil., Moreno NC; National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Genomic Integrity, Bethesda, MD, USA., Latancia MT; National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Genomic Integrity, Bethesda, MD, USA., Rocha CRR; Universidade Federal de São Paulo (UNIFESP), Departamento de Oncologia Clínica e Experimental, São Paulo, SP, Brazil. |
| المصدر: | Genetics and molecular biology [Genet Mol Biol] 2024 May 31; Vol. 47 (Suppl 1), pp. e20230317. Date of Electronic Publication: 2024 May 31 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Genética Country of Publication: Brazil NLM ID: 100883590 Publication Model: eCollection Cited Medium: Print ISSN: 1415-4757 (Print) Linking ISSN: 14154757 NLM ISO Abbreviation: Genet Mol Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Ribeirão Preto, SP, Brazil : Sociedade Brasileira de Genética, 1998- |
| مستخلص: | In the search for alternatives to overcome the challenge imposed by drug resistance development in cancer treatment, the modulation of autophagy has emerged as a promising alternative that has achieved good results in clinical trials. Nevertheless, most of these studies have overlooked a novel and selective type of autophagy: chaperone-mediated autophagy (CMA). Following its discovery, research into CMA's contribution to tumor progression has accelerated rapidly. Therefore, we now understand that stress conditions are the primary signal responsible for modulating CMA in cancer cells. In turn, the degradation of proteins by CMA can offer important advantages for tumorigenesis, since tumor suppressor proteins are CMA targets. Such mutual interaction between the tumor microenvironment and CMA also plays a crucial part in establishing therapy resistance, making this discussion the focus of the present review. Thus, we highlight how suppression of LAMP2A can enhance the sensitivity of cancer cells to several drugs, just as downregulation of CMA activity can lead to resistance in certain cases. Given this panorama, it is important to identify selective modulators of CMA to enhance the therapeutic response. |
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| تواريخ الأحداث: | Date Created: 20240603 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC11145944 |
| DOI: | 10.1590/1678-4685-GMB-2023-0317 |
| PMID: | 38829285 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1415-4757 |
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| DOI: | 10.1590/1678-4685-GMB-2023-0317 |