دورية أكاديمية
T2-FLAIR mismatch sign predicts DNA methylation subclass and CDKN2A/B status in IDH-mutant astrocytomas.
| العنوان: | T2-FLAIR mismatch sign predicts DNA methylation subclass and CDKN2A/B status in IDH-mutant astrocytomas. |
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| المؤلفون: | Lee MD; New York University Langone Medical Center, New York, United States., Jain R; New York University Langone Medical Center, New York, United States., Galbraith K; New York University Langone Medical Center, New York, New York, United States., Chen A; New York University Langone Medical Center, United States., Lieberman E; New York University Langone Medical Center, New York, NY, United States., Patel SH; University of Virginia Health System, United States., Placantonakis DG; New York University Langone Medical Center, New York, NY, United States., Zagzag D; New York University School of Medicine, New York, NY, United States., Barbaro M; New York University Langone Medical Center, New York, New York, United States., Guillermo Prieto Eibl MDP; New York University Langone Medical Center, United States., Golfinos JG; New York University Langone Medical Center, New York, NY, United States., Orringer DA; New York University Langone Medical Center, New York, New York, United States., Snuderl M; NYU Langone Medical Center, New York, NY, United States. |
| المصدر: | Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Jun 03. Date of Electronic Publication: 2024 Jun 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Denville, NJ : The Association, c1995- |
| مستخلص: | Purpose: DNA methylation profiling stratifies isocitrate dehydrogenase (IDH)-mutant astrocytomas into methylation low-grade and high-grade groups. We investigated the utility of the T2-FLAIR mismatch sign for predicting DNA methylation grade and cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) homozygous deletion, a molecular biomarker for grade 4 IDH-mutant astrocytomas, according to the 2021 World Health Organization (WHO) classification. Experimental Design: Preoperative MRI scans of IDH-mutant astrocytomas subclassified by DNA methylation profiling (n=71) were independently evaluated by two radiologists for the T2-FLAIR mismatch sign. The diagnostic utility of T2-FLAIR mismatch in predicting methylation grade, CDKN2A/B status, copy number variation, and survival was analyzed. Results: The T2-FLAIR mismatch sign was present in 21 of 45 (46.7%) methylation low-grade and 1 of 26 (3.9%) methylation high-grade cases (p<0.001), resulting in 96.2% specificity, 95.5% positive predictive value, and 51.0% negative predictive value for predicting low methylation grade. The T2-FLAIR mismatch sign was also significantly associated with intact CDKN2A/B status (p=0.028) with 87.5% specificity, 86.4% positive predictive value, and 42.9% negative predictive value. Overall multivariable Cox analysis showed that retained CDKN2A/B status remained significant for PFS (p=0.01). Multivariable Cox analysis of the histologic grade 3 subset, which was nearly evenly divided by CDKN2A/B status, CNV, and methylation grade, showed trends toward significance for DNA methylation grade with OS (p=0.045) and CDKN2A/B status with PFS (p=0.052). Conclusions: The T2-FLAIR mismatch sign is highly specific for low methylation grade and intact CDKN2A/B in IDH-mutant astrocytomas. |
| تواريخ الأحداث: | Date Created: 20240603 Latest Revision: 20240603 |
| رمز التحديث: | 20240603 |
| DOI: | 10.1158/1078-0432.CCR-24-0311 |
| PMID: | 38829583 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-3265 |
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| DOI: | 10.1158/1078-0432.CCR-24-0311 |