دورية أكاديمية
أعرض في EDS

Description of mitochondrial oxygen tension and its variability in healthy volunteers.

التفاصيل البيبلوغرافية
العنوان: Description of mitochondrial oxygen tension and its variability in healthy volunteers.
المؤلفون: Baysan M; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Jon J van Rood Center for Clinical Transfusion Research, Sanquin/Leiden University Medical Center, Leiden, the Netherlands., Broere M; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Jon J van Rood Center for Clinical Transfusion Research, Sanquin/Leiden University Medical Center, Leiden, the Netherlands., Wille ME; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands., Bergsma JE; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands., Mik EG; Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus MC- University Medical Center Rotterdam, Rotterdam, the Netherlands., Juffermans NP; Department of Intensive Care Medicine, OLVG Hospital, Amsterdam, the Netherlands.; Department of Laboratory of Translation Intensive Care, Erasmus MC- University Medical Center Rotterdam, Rotterdam, the Netherlands., Tsonaka R; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., van der Bom JG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Jon J van Rood Center for Clinical Transfusion Research, Sanquin/Leiden University Medical Center, Leiden, the Netherlands., Arbous SM; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
المصدر: PloS one [PLoS One] 2024 Jun 03; Vol. 19 (6), pp. e0300602. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Healthy Volunteers* , Oxygen*/metabolism, Humans ; Male ; Female ; Adult ; Prospective Studies ; Mitochondria/metabolism ; Middle Aged ; Aminolevulinic Acid/administration & dosage ; Oxygen Consumption ; Young Adult ; Netherlands
مستخلص: Objectives: Describing mitochondrial oxygenation (mitoPO2) and its within- and between-subject variability over time after 5-aminolevulinic acid (ALA) plaster application in healthy volunteers.
Design: Prospective cohort study.
Setting: Measurements were performed in Leiden University Medical Center, the Netherlands.
Participants: Healthy volunteers enrolled from July to September 2020.
Interventions: Two ALA plasters were placed parasternal left and right, with a 3-hour time interval, to examine the influence of the calendar time on the value of mitoPO2. We measured mitoPO2 at 4, 5, 7, 10, 28, and 31 hours after ALA plaster 1 application, and at 4, 5, 7, 25, and 28 hours after ALA plaster 2 application.
Primary and Secondary Outcome Measures: At each time point, five mitoPO2 measurements were performed. Within-subject variability was defined as the standard deviation (SD) of the mean of five measurements per timepoint of a study participant. The between-subject variability was the SD of the mean mitoPO2 value of the study population per timepoint.
Results: In 16 completed inclusions, median mitoPO2 values and within-subject variability were relatively similar over time at all time points for both plasters. An increase in overall between-subject variability was seen after 25 hours ALA plaster time (19.6 mm Hg vs 23.9 mm Hg after respectively 10 and 25 hours ALA plaster time).
Conclusions: The mitoPO2 values and within-subject variability remained relatively stable over time in healthy volunteers. An increase in between-subject variability was seen after 25 hours ALA plaster time warranting replacement of the ALA plaster one day after its application.
Trial Registration: ClinicalTrials.gov with trial number NCT04626661.
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: E.G. Mik is a founder and shareholder of Photonics Healthcare B.V. (Utrecht, The Netherlands). Photonics Healthcare develops and commercializes the COMET measuring system for mitochondrial oxygen measurements. The other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2024 Baysan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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سلسلة جزيئية: ClinicalTrials.gov NCT04626661
المشرفين على المادة: S88TT14065 (Oxygen)
88755TAZ87 (Aminolevulinic Acid)
تواريخ الأحداث: Date Created: 20240603 Date Completed: 20240603 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC11146699
DOI: 10.1371/journal.pone.0300602
PMID: 38829894
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0300602