التفاصيل البيبلوغرافية
| العنوان: |
The Secret Ballet Inside Multivesicular Bodies. |
| المؤلفون: |
Mayorga LS; Instituto de Histología y Embriología de Mendoza (IHEM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCuyo), 5500 Mendoza, Argentina.; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo (UNCuyo), 5500, Mendoza, Argentina., Masone D; Instituto de Histología y Embriología de Mendoza (IHEM), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Cuyo (UNCuyo), 5500 Mendoza, Argentina.; Facultad de Ingeniería, Universidad Nacional de Cuyo (UNCuyo), 5500 Mendoza, Argentina. |
| المصدر: |
ACS nano [ACS Nano] 2024 Jun 18; Vol. 18 (24), pp. 15651-15660. Date of Electronic Publication: 2024 Jun 03. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Washington D.C. : American Chemical Society |
| مواضيع طبية MeSH: |
Multivesicular Bodies*/metabolism, Lipid Bilayers/chemistry ; Lipid Bilayers/metabolism ; Entropy ; Hydrophobic and Hydrophilic Interactions |
| مستخلص: |
Lipid bilayers possess the capacity for self-assembly due to the amphipathic nature of lipid molecules, which have both hydrophobic and hydrophilic regions. When confined, lipid bilayers exhibit astonishing versatility in their forms, adopting diverse shapes that are challenging to observe through experimental means. Exploiting this adaptability, lipid structures motivate the development of bio-inspired mechanomaterials and integrated nanobio-interfaces that could seamlessly merge with biological entities, ultimately bridging the gap between synthetic and biological systems. In this work, we demonstrate how, in numerical simulations of multivesicular bodies, a fascinating evolution unfolds from an initial semblance of order toward states of higher entropy over time. We observe dynamic rearrangements in confined vesicles that reveal unexpected limit shapes of distinct geometric patterns. We identify five structures as the basic building blocks that systematically repeat under various conditions of size and composition. Moreover, we observe more complex and less frequent shapes that emerge in confined spaces. Our results provide insights into the dynamics of multivesicular systems, offering a richer understanding of how confined lipid bodies spontaneously self-organize. |
| فهرسة مساهمة: |
Keywords: leaflet segmentation; limit shapes; lipid monolayers; molecular dynamics; multivesicular bodies |
| المشرفين على المادة: |
0 (Lipid Bilayers) |
| تواريخ الأحداث: |
Date Created: 20240603 Date Completed: 20240618 Latest Revision: 20240618 |
| رمز التحديث: |
20240619 |
| DOI: |
10.1021/acsnano.4c01590 |
| PMID: |
38830824 |
| قاعدة البيانات: |
MEDLINE |
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