دورية أكاديمية
أعرض في EDS

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

التفاصيل البيبلوغرافية
العنوان: Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.
المؤلفون: Li X; Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA., Kirkpatrick RB; Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA., Wang X; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Tucker CJ; Fluorescence Microscopy and Imaging Center, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA., Shukla A; Institute of Organic Chemistry, and CIBSS - the Center for Integrative Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany., Jessen HJ; Institute of Organic Chemistry, and CIBSS - the Center for Integrative Biological Signaling Studies, University of Freiburg, 79104 Freiburg, Germany., Wang H; Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA; Nucleolar Integrity Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA., Shears SB; Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA., Gu C; Inositol Signaling Group, Signal Transduction Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA; Synaptic & Developmental Plasticity Group, Neurobiology Laboratory, National Institute of Environmental, Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: guc2@nih.gov.
المصدر: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114316. Date of Electronic Publication: 2024 Jun 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Homeostasis* , Inositol Phosphates*/metabolism, Humans ; Animals ; Xenotropic and Polytropic Retrovirus Receptor ; HEK293 Cells ; Organelles/metabolism ; Biological Transport ; Phosphates/metabolism ; Mice
مستخلص: Phosphate (Pi) serves countless metabolic pathways and is involved in macromolecule synthesis, energy storage, cellular signaling, and bone maintenance. Herein, we describe the coordination of Pi uptake and efflux pathways to maintain mammalian cell Pi homeostasis. We discover that XPR1, the presumed Pi efflux transporter, separately supervises rates of Pi uptake. This direct, regulatory interplay arises from XPR1 being a binding partner for the Pi uptake transporter PiT1, involving a predicted transmembrane helix/extramembrane loop in XPR1, and its hitherto unknown localization in a subset of intracellular LAMP1-positive puncta (named "XLPVs"). A pharmacological mimic of Pi homeostatic challenge is sensed by the inositol pyrophosphate IP 8 , which functionalizes XPR1 to respond in a temporally hierarchal manner, initially adjusting the rate of Pi efflux, followed subsequently by independent modulation of PiT1 turnover to reset the rate of Pi uptake. These observations generate a unifying model of mammalian cellular Pi homeostasis, expanding opportunities for therapeutic intervention.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Published by Elsevier Inc.)
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معلومات مُعتمدة: Z99 ES999999 United States ImNIH Intramural NIH HHS
فهرسة مساهمة: Keywords: CP: Molecular biology; IP8; PPIP5K; Pi efflux; Pi homeostasis; PiT1; SLC20A1; XPR1; inorganic phosphate; inositol pyrophosphate; lysosome
المشرفين على المادة: 0 (Inositol Phosphates)
0 (Xenotropic and Polytropic Retrovirus Receptor)
0 (Phosphates)
تواريخ الأحداث: Date Created: 20240604 Date Completed: 20240701 Latest Revision: 20240730
رمز التحديث: 20240730
مُعرف محوري في PubMed: PMC11284862
DOI: 10.1016/j.celrep.2024.114316
PMID: 38833370
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2024.114316