دورية أكاديمية
أعرض في EDS

Research Letter: Relationship of Blood Biomarkers of Inflammation With Acute Concussion Symptoms and Recovery in the CARE Consortium.

التفاصيل البيبلوغرافية
العنوان: Research Letter: Relationship of Blood Biomarkers of Inflammation With Acute Concussion Symptoms and Recovery in the CARE Consortium.
المؤلفون: Meier TB; Author Affiliations: Department of Neurosurgery (Dr Meier, Mr Huber, and Dr McCrea), Department of Biomedical Engineering (Dr Meier), Department of Biophysics (Ms Goeckner), Department of Cell Biology, Neurobiology and Anatomy (Dr Meier), Department of Neurology (Dr McCrea), Medical College of Wisconsin, Milwaukee, Wisconsin; National Institute of Nursing Research (Dr Gill), National Institutes of Health, Bethesda, Maryland, USA; Johns Hopkins School of Nursing and Medicine (Dr Gill), Baltimore, MD; Department of Physical Medicine and Rehabilitation (Dr Pasquina), Uniformed Services University of the Health Sciences, Bethesda, Maryland; Michigan Concussion Center (Dr Broglio), University of Michigan, Ann Arbor, Michigan; Department of Psychiatry (Dr McAllister), Indiana University School of Medicine, Indianapolis, IN; and Department of Epidemiology and Biostatistics (Dr Harezlak), School of Public Health-Bloomington, Indiana University, Bloomington, Indiana., Huber DL, Goeckner BD, Gill JM, Pasquina P, Broglio SP, McAllister TW, Harezlak J, McCrea MA
مؤلفون مشاركون: CARE Consortium Investigators
المصدر: The Journal of head trauma rehabilitation [J Head Trauma Rehabil] 2024 May 31. Date of Electronic Publication: 2024 May 31.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Aspen Publications Country of Publication: United States NLM ID: 8702552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-509X (Electronic) Linking ISSN: 08859701 NLM ISO Abbreviation: J Head Trauma Rehabil Subsets: MEDLINE
أسماء مطبوعة: Publication: Gaithersburg Md : Aspen Publications
Original Publication: [Gaithersburg, Md.] : Aspen, [c1986-
مستخلص: Objective: Determine the association of inflammatory biomarkers with clinical measures and recovery in participants with concussion.
Setting: Multicenter study in National Collegiate Athletic Association member institutions including military service academies.
Participants: Four hundred twenty-two participants with acute concussion.
Design: Clinical visits and blood draws were completed preinjury and at multiple visits postconcussion (0-12 hours, 12-36 hours, and 36-60 hours postinjury). Clinical measures included Sport Concussion Assessment Tool (SCAT) symptom severity, Balance Error Scoring System, Standardized Assessment of Concussion (SAC), Brief Symptom Inventory-18 (BSI-18) scores, time to initiation of graduated return-to-play (RTP) protocol, and time to RTP. Interleukin (IL)-6, IL-10, IL-8, IL-1 receptor antagonist (RA), tumor necrosis factor (TNF), c-reactive protein, and vascular endothelial growth factor (VEGF) were measured in serum. Prespecified analyses focused on IL-6 and IL-1RA at 0 to 12 hours; exploratory analyses were conducted with false discovery rate correction.
Results: For prespecified analyses, IL-1RA at 0 to 12 hours in female participants was positively associated with more errors on the SAC (B(standard error, SE) = 0.58(0.27), P < .05) and worse SCAT symptom severity (B(SE) = 0.96(0.44), P < .05). For exploratory analyses, higher levels of IL-1RA at 12 to 36 hours were associated with higher global (B(SE) = 0.55(0.14), q < 0.01), depression (B(SE) = 0.45(0.10), q < 0.005), and somatization scores on the BSI (B(SE) = 0.46(0.12), q < 0.01) in participants with concussion; Higher TNF at 12 to 36 hours was associated with fewer errors on the SAC (B(SE) = - 0.46(0.14), q < 0.05). Subanalyses showed similar results for male participants and participants who were athletes. No associations were discovered in nonathlete cadets. Higher IL-8 at 0 to 12 hours was associated with slower RTP in female participants (OR = 14.47; 95% confidence interval, 2.96-70.66, q < 0.05); no other associations with recovery were observed.
Conclusions: Peripheral inflammatory markers are associated with clinical symptoms following concussion and potentially represent one mechanism for psychological symptoms observed postinjury. Current results do not provide strong support for a potential prognostic role for these markers.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
References: Morganti-Kossmann MC, Semple BD, Hellewell SC, Bye N, Ziebell JM. The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments. Acta Neuropathol. 2019;137(5):731–755. doi:10.1007/s00401-018-1944-6. (PMID: 10.1007/s00401-018-1944-6)
Meier TB, Huber DL, Bohorquez-Montoya L, et al. A prospective study of acute blood-based biomarkers for sport-related concussion. Ann Neurol. 06 2020;87(6):907–920. doi:10.1002/ana.25725. (PMID: 10.1002/ana.25725)
Nitta ME, Savitz J, Nelson LD, et al. Acute elevation of serum inflammatory markers predicts symptom recovery after concussion. Neurology. 07 30 2019;93(5):e497–e507. doi:10.1212/WNL.0000000000007864. (PMID: 10.1212/WNL.0000000000007864)
Visser K, Koggel M, Blaauw J, van der Horn HJ, Jacobs B, van der Naalt J. Blood-based biomarkers of inflammation in mild traumatic brain injury: a systematic review. Neurosci Biobehav Rev. 2022 01;132:154–168. doi:10.1016/j.neubiorev.2021.11.036. (PMID: 10.1016/j.neubiorev.2021.11.036)
Meier TB, Huber DL, Goeckner BD, et al. Association of blood biomarkers of inflammation with acute concussion in collegiate athletes and military service academy cadets. Neurology. 01 23 2024;102(2):e207991. doi:10.1212/WNL.0000000000207991. (PMID: 10.1212/WNL.0000000000207991)
Van Pelt KL, Allred CD, Brodeur R, et al. Concussion-recovery trajectories among tactical athletes: results from the CARE Consortium. J Athl Train. Jul 01 2020;55(7):658–665. doi:10.4085/1062-6050-10-19. (PMID: 10.4085/1062-6050-10-19)
Bretzin AC, Esopenko C, D’Alonzo BA, Wiebe DJ. Clinical recovery timelines after sport-related concussion in Men’s and Women’s collegiate sports. J Athl Train. Jul 01 2022;57(7):678–687. doi:10.4085/601-20. (PMID: 10.4085/601-20)
Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016 Oct;16(10):626–638. doi:10.1038/nri.2016.90. (PMID: 10.1038/nri.2016.90)
Broglio SP, McCrea M, McAllister T, et al. A national study on the effects of concussion in collegiate athletes and US Military Service Academy Members: the NCAA–DoD Concussion Assessment, Research and Education (CARE) Consortium structure and methods. Sports Med. 2017;47(7):1437–1451. doi:10.1007/s40279-017-0707-1. (PMID: 10.1007/s40279-017-0707-1)
Carney N, Ghajar J, Jagoda A, et al. Executive summary of concussion guidelines step 1: systematic review of prevalent indicators. Neurosurgery. 2014;75(SUPPL. 1):S3–S15.doi:10.1227/NEU.0000000000000434. (PMID: 10.1227/NEU.0000000000000434)
Manley GT, Diaz-Arrastia R, Brophy M, et al. Common data elements for traumatic brain injury: recommendations from the biospecimens and biomarkers working group. Arch Phys Med Rehabil. 2010;91(11):1667–1672. doi:10.1016/j.apmr.2010.05.018. (PMID: 10.1016/j.apmr.2010.05.018)
Arend WP, Malyak M, Guthridge CJ, Gabay C. Interleukin-1 receptor antagonist: role in biology. Annu Rev Immunol. 1998;16(1):27–55. doi:10.1146/annurev.immunol.16.1.27. (PMID: 10.1146/annurev.immunol.16.1.27)
Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD. Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls. Brain Behav Immun. Jul 2020;87:901–909. doi:10.1016/j.bbi.2020.02.010. (PMID: 10.1016/j.bbi.2020.02.010)
Křenek P, Hořínková J, Bartečků E. Peripheral inflammatory markers in subtypes and core features of depression: a systematized review. Psychopathology. 2023;56(6):403–416. doi:10.1159/000528907. (PMID: 10.1159/000528907)
Valera EM, Joseph AC, Snedaker K, et al. Understanding traumatic brain injury in females: a state-of-the-art summary and future directions. J Head Trauma Rehabil. Jan 1 2021;36(1):E1–E17. doi:10.1097/HTR.0000000000000652. (PMID: 10.1097/HTR.0000000000000652)
تواريخ الأحداث: Date Created: 20240604 Latest Revision: 20240604
رمز التحديث: 20240605
DOI: 10.1097/HTR.0000000000000956
PMID: 38833710
قاعدة البيانات: MEDLINE
الوصف
تدمد:1550-509X
DOI:10.1097/HTR.0000000000000956