دورية أكاديمية
Generation of CAR-T SCM : CAR-T with super clutch.
| العنوان: | Generation of CAR-T |
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| المؤلفون: | Hu J; Department of Laboratory Medicine, Gongli Hospital, No. 219, Miaopu Road, Pudong, Shanghai, 200135, China. Electronic address: hjh7677@sina.com., Liu X; TriArm Therapeutics Inc, Building 5, Niudun Road, Pudong New District, Shanghai, 201203, China. Electronic address: xiang.liu@triarmbio.com. |
| المصدر: | International immunopharmacology [Int Immunopharmacol] 2024 Jul 30; Vol. 136, pp. 112379. Date of Electronic Publication: 2024 Jun 03. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Immunotherapy, Adoptive*/methods , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/genetics , T-Lymphocytes*/immunology, Humans ; Animals ; Cell Differentiation ; Neoplasms/therapy ; Neoplasms/immunology |
| مستخلص: | CAR-T therapy has demonstrated effectiveness in hematological malignancies and is now striding into solid tumor areas. One of the main roadblocks of CAR-T therapy is T cell exhaustion normally aroused by T cell terminal differentiation due to persistent contact with antigen in vivo or in vitro manufacturing process. T Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CAR; CAR-T; CAR-T(SCM); T stem cell like memory; T(SCM) |
| المشرفين على المادة: | 0 (Receptors, Chimeric Antigen) |
| تواريخ الأحداث: | Date Created: 20240604 Date Completed: 20240615 Latest Revision: 20240625 |
| رمز التحديث: | 20240625 |
| DOI: | 10.1016/j.intimp.2024.112379 |
| PMID: | 38833844 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-1705 |
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| DOI: | 10.1016/j.intimp.2024.112379 |