دورية أكاديمية
Thiazide-Induced Hyponatremia Presenting as a Fall in an Older Adult.
| العنوان: | Thiazide-Induced Hyponatremia Presenting as a Fall in an Older Adult. |
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| المؤلفون: | Pagliuca S; New England Geriatrics Research, Education, and Clinical Center (GRECC), Veterans Affairs Boston Healthcare System, Massachusetts.; Boston University Chobanian & Avedisian School of Medicine, Massachusetts., Wagner C; Veterans Affairs Boston Healthcare System, Massachusetts., Pietruszka BL; Veterans Affairs Boston Healthcare System, Massachusetts., Jindal SK; Boston University Chobanian & Avedisian School of Medicine, Massachusetts.; Veterans Affairs Boston Healthcare System, Massachusetts.; Cincinnati Veterans Affairs Medical Center, Ohio. |
| المصدر: | Federal practitioner : for the health care professionals of the VA, DoD, and PHS [Fed Pract] 2024 Feb; Vol. 41 (2), pp. 58-61. Date of Electronic Publication: 2024 Feb 16. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontline Medical Communications Country of Publication: United States NLM ID: 9500574 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1078-4497 (Print) Linking ISSN: 10784497 NLM ISO Abbreviation: Fed Pract Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Parsippany, NJ : Frontline Medical Communications Original Publication: Belle Mead, N.J. : Excerpta Medica, Inc., 1994- |
| مستخلص: | Background: Regardless of age, first-line therapy for uncomplicated hypertension includes thiazide diuretics, long-acting calcium channel blockers, and renin-angiotensin system inhibitors. Even though older adults are often at increased risk of adverse drug events, specific guidelines for choosing between different classes of antihypertensives are lacking. Given the prevalence of hypertension in older adults, clinicians should be aware of the increased risk of electrolyte disorders after the initiation of thiazide diuretics in this population. Case Presentation: A patient aged > 90 years fell getting out of his bed 2 weeks following initiation of hydrochlorothiazide 25 mg daily medication therapy. Laboratory tests revealed a urine sodium of 35 mmol/L most consistent with hypovolemic hypoosmotic hyponatremia secondary to thiazide initiation. Hydrochlorothiazide was discontinued and sodium gradually normalized over the next 2 weeks without any other intervention. Conclusions: Despite being recommended as first-line therapy for uncomplicated hypertension, thiazide diuretics may cause more harm than good in older adults with risk factors for thiazide-induced hyponatremia, which should be considered before initiation. Competing Interests: Author disclosures: The authors report no actual or potential conflicts of interest or outside sources of funding with regard to this article. (Copyright © 2024 Frontline Medical Communications Inc., Parsippany, NJ, USA.) |
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| تواريخ الأحداث: | Date Created: 20240605 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC11147435 |
| DOI: | 10.12788/fp.0443 |
| PMID: | 38835924 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1078-4497 |
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| DOI: | 10.12788/fp.0443 |