دورية أكاديمية

Research progress on GPX4 targeted compounds.

التفاصيل البيبلوغرافية
العنوان: Research progress on GPX4 targeted compounds.
المؤلفون: Li B; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Cheng K; School of Chemistry and Pharmaceutical Sciences, State/Ministry of Education of China Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, China., Wang T; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Peng X; Changping Laboratory, Yard 28, Science Park Road, Changping District, Beijing, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Xu P; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Liu G; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China., Xue D; Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, China., Jiao N; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China; Changping Laboratory, Yard 28, Science Park Road, Changping District, Beijing, China., Wang C; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China. Electronic address: wangchao@bjmu.edu.cn.
المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Aug 05; Vol. 274, pp. 116548. Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: Paris, S.E.C.T. [etc.]
مواضيع طبية MeSH: Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/antagonists & inhibitors, Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/chemical synthesis ; Molecular Structure ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/metabolism ; Ferroptosis/drug effects ; Animals
مستخلص: Blocking the System X c -_ GSH _ GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein, including inhibitors, activators, small molecule degraders, chimeric degraders, and the application of combination therapies with other drugs, aiming to promote further research on the target and related diseases.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Chao Wang reports financial support was provided by National Natural Science Foundation of China. Chao Wang reports financial support was provided by Peking University Medicine Seed Fund for Interdisciplinary Research and the Fundamental Research Funds for the Central Universities. Chao Wang reports financial support was provided by State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University). Chao Wang reports financial support was provided by Key Laboratory of Applied Surface and Colloid Chemistry (Shaanxi Normal University), Ministry of Education. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
المشرفين على المادة: EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase)
0 (Antineoplastic Agents)
0 (Enzyme Inhibitors)
تواريخ الأحداث: Date Created: 20240605 Date Completed: 20240615 Latest Revision: 20240618
رمز التحديث: 20240619
DOI: 10.1016/j.ejmech.2024.116548
PMID: 38838547
قاعدة البيانات: MEDLINE
الوصف
تدمد:1768-3254
DOI:10.1016/j.ejmech.2024.116548