دورية أكاديمية
Nuclear position and local acetyl-CoA production regulate chromatin state.
| العنوان: | Nuclear position and local acetyl-CoA production regulate chromatin state. |
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| المؤلفون: | Willnow P; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Heidelberg University, Heidelberg, Germany., Teleman AA; German Cancer Research Center (DKFZ), Heidelberg, Germany. a.teleman@dkfz.de.; Heidelberg University, Heidelberg, Germany. a.teleman@dkfz.de. |
| المصدر: | Nature [Nature] 2024 Jun; Vol. 630 (8016), pp. 466-474. Date of Electronic Publication: 2024 Jun 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Acetyl Coenzyme A*/metabolism , Cell Nucleus*/genetics , Cell Nucleus*/metabolism , Chromatin*/metabolism , Chromatin*/genetics , Drosophila melanogaster*/enzymology , Drosophila melanogaster*/genetics , Drosophila melanogaster*/growth & development , Drosophila melanogaster*/metabolism, Animals ; Acetate-CoA Ligase/metabolism ; Acetylation ; Biological Transport ; Drosophila Proteins/metabolism ; Drosophila Proteins/genetics ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Gene Expression Regulation ; Histones/chemistry ; Histones/metabolism ; Imaginal Discs/cytology ; Imaginal Discs/growth & development ; Imaginal Discs/metabolism ; Lysine/metabolism ; Oxidation-Reduction ; Wings, Animal/cytology ; Wings, Animal/growth & development ; Wings, Animal/metabolism |
| مستخلص: | Histone acetylation regulates gene expression, cell function and cell fate 1 . Here we study the pattern of histone acetylation in the epithelial tissue of the Drosophila wing disc. H3K18ac, H4K8ac and total lysine acetylation are increased in the outer rim of the disc. This acetylation pattern is controlled by nuclear position, whereby nuclei continuously move from apical to basal locations within the epithelium and exhibit high levels of H3K18ac when they are in proximity to the tissue surface. These surface nuclei have increased levels of acetyl-CoA synthase, which generates the acetyl-CoA for histone acetylation. The carbon source for histone acetylation in the rim is fatty acid β-oxidation, which is also increased in the rim. Inhibition of fatty acid β-oxidation causes H3K18ac levels to decrease in the genomic proximity of genes involved in disc development. In summary, there is a physical mark of the outer rim of the wing and other imaginal epithelia in Drosophila that affects gene expression. (© 2024. The Author(s).) |
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| المشرفين على المادة: | EC 6.2.1.1 (Acetate-CoA Ligase) 72-89-9 (Acetyl Coenzyme A) 0 (Chromatin) 0 (Drosophila Proteins) 0 (Fatty Acids) 0 (Histones) K3Z4F929H6 (Lysine) |
| تواريخ الأحداث: | Date Created: 20240605 Date Completed: 20240612 Latest Revision: 20240623 |
| رمز التحديث: | 20240623 |
| مُعرف محوري في PubMed: | PMC11168921 |
| DOI: | 10.1038/s41586-024-07471-4 |
| PMID: | 38839952 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-4687 |
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| DOI: | 10.1038/s41586-024-07471-4 |