دورية أكاديمية
أعرض في EDS

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.

التفاصيل البيبلوغرافية
العنوان: Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a systematic review of in vitro studies.
المؤلفون: Castellanos JS; Departamento de Salud Oral, Facultad de Odontología, Universidad Nacional de Colombia. Av, Cra 30 No. 45-03, Edificio 210, Of. 311, Bogotá, Colombia., Betancourt DE; Departamento de Salud Oral, Facultad de Odontología, Universidad Nacional de Colombia. Av, Cra 30 No. 45-03, Edificio 210, Of. 311, Bogotá, Colombia., Díaz-Báez D; Unit of Oral Basic Investigation - UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia., Baldión PA; Departamento de Salud Oral, Facultad de Odontología, Universidad Nacional de Colombia. Av, Cra 30 No. 45-03, Edificio 210, Of. 311, Bogotá, Colombia. pabaldione@unal.edu.co.
المصدر: BMC oral health [BMC Oral Health] 2024 Jun 05; Vol. 24 (1), pp. 662. Date of Electronic Publication: 2024 Jun 05.
نوع المنشور: Journal Article; Systematic Review; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088684 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6831 (Electronic) Linking ISSN: 14726831 NLM ISO Abbreviation: BMC Oral Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Streptococcus mutans*/drug effects , Vaccinium macrocarpon*/chemistry , Plant Extracts*/pharmacology , Flavonoids*/pharmacology , Grape Seed Extract*/pharmacology, Biofilms/drug effects ; Humans ; Vitis ; Proanthocyanidins/pharmacology
مستخلص: Objective: To provide an overview of the available scientific evidence from in vitro studies regarding the effect induced by the flavonoids contained in grape seed extracts (GSE) and cranberry on the microbiological activity of Streptococcus mutans (S. mutans).
Methods: This systematic review was performed following the parameters of the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). Electronic and manual searches were conducted using PubMed, ScienceDirect, Web of Science, EBSCO, and Cochrane databases. Reference lists of selected articles were reviewed to identify relevant studies. The search was not limited by year and was conducted solely in English. Eligible studies comprised publications describing in vitro studies that evaluated the effect of flavonoids derived from GSE and cranberry extracts on the microbiological activity of S. mutans. Common variables were identified to consolidate the data. Authors of this review independently screened search results, extracted data, and assessed the risk of bias.
Results: Of the 420 studies identified from the different databases, 22 publications were finally selected for review. The risk of bias was low in 13 articles and moderate in 9. The studies analyzed in this review revealed that cranberry extract has an inhibitory effect on the bacterial growth of S. mutans in ranges from 0.5 mg/mL to 25 mg/mL, and GSE exerts a similar effect from 0.5 mg/mL to 250 mg/mL. Additionally, the extracts or their fractions showed reduced biofilm formation capacity, decreased polymicrobial biofilm biomass, deregulation of glycosyltransferases (Gtf) B and C expression, and buffering of pH drop. In addition to adequate antioxidant activity related to polyphenol content.
Conclusions: The overall results showed that the extracts of cranberry and grape seed were effective in reducing the virulence factors of the oral pathogen. According to the data, proanthocyanidins are the active components in cranberry and grape seed that effectively resist S. mutans. They can inhibit the formation of insoluble polysaccharides in the extracellular matrix and prevent glycan-mediated adhesion, cohesion, and aggregation of the proteins in S. mutans. This suggests that these natural extracts could play an important role in the prevention of cariogenic bacterial colonization, as well as induce a decrease in their microbiological activity.
(© 2024. The Author(s).)
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معلومات مُعتمدة: HERMES code 57561 Universidad Nacional de Colombia; HERMES code 57561 Universidad Nacional de Colombia; HERMES code 57561 Universidad Nacional de Colombia
فهرسة مساهمة: Keywords: Streptococcus mutans; Cranberry; Dental caries; Grape seed extract; Proanthocyanidin
المشرفين على المادة: 0 (Plant Extracts)
0 (Flavonoids)
0 (Grape Seed Extract)
0 (Proanthocyanidins)
تواريخ الأحداث: Date Created: 20240605 Date Completed: 20240606 Latest Revision: 20240709
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11155149
DOI: 10.1186/s12903-024-04263-0
PMID: 38840232
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6831
DOI:10.1186/s12903-024-04263-0