دورية أكاديمية
أعرض في EDS

Transcriptomic gene signatures measure satellite cell activity in muscular dystrophies.

التفاصيل البيبلوغرافية
العنوان: Transcriptomic gene signatures measure satellite cell activity in muscular dystrophies.
المؤلفون: Engquist EN; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, London SE1 1UL, UK., Greco A; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6525 GA, the Netherlands.; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen 6525 GA, The Netherlands., Joosten LAB; Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen 6525 GA, The Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University if Medicine and Pharmacy, 400012 Cluj-Napoca, Romania., van Engelen BGM; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6525 GA, the Netherlands., Banerji CRS; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, London SE1 1UL, UK.; The Alan Turing Institute, The British Library, 96 Euston Road, London NW1 2DB, UK.; University College London Hospitals, NHS Foundation Trust, London NW1 2BU, UK., Zammit PS; King's College London, Randall Centre for Cell and Molecular Biophysics, New Hunt's House, Guy's Campus, London SE1 1UL, UK.
المصدر: IScience [iScience] 2024 May 08; Vol. 27 (6), pp. 109947. Date of Electronic Publication: 2024 May 08 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: The routine need for myonuclear turnover in skeletal muscle, together with more sporadic demands for hypertrophy and repair, are performed by resident muscle stem cells called satellite cells. Muscular dystrophies are characterized by muscle wasting, stimulating chronic repair/regeneration by satellite cells. Here, we derived and validated transcriptomic signatures for satellite cells, myoblasts/myocytes, and myonuclei using publicly available murine single cell RNA-Sequencing data. Our signatures distinguished disease from control in transcriptomic data from several muscular dystrophies including facioscapulohumeral muscular dystrophy (FSHD), Duchenne muscular dystrophy, and myotonic dystrophy type I. For FSHD, the expression of our gene signatures correlated with direct counts of satellite cells on muscle sections, as well as with increasing clinical and pathological severity. Thus, our gene signatures enable the investigation of myogenesis in bulk transcriptomic data from muscle biopsies. They also facilitate study of muscle regeneration in transcriptomic data from human muscle across health and disease.
Competing Interests: BGMvE declares personal fees and non-financial support from Fulcrum, and Facio during the conduct of the study and has a patent EP20120740236 with royalties paid to Euroimmun. ENE, AG, LABJ, PSZ and CRSB declare no conflicts of interest.
(© 2024 The Authors.)
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فهرسة مساهمة: Keywords: disease; model organism; musculoskeletal medicine; specialized functions of cells; transcriptomics
تواريخ الأحداث: Date Created: 20240606 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC11150970
DOI: 10.1016/j.isci.2024.109947
PMID: 38840844
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2024.109947