دورية أكاديمية
Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers After Coronary Artery Bypass Graft Surgery: A Population-Based Cohort Study.
| العنوان: | Effect of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers After Coronary Artery Bypass Graft Surgery: A Population-Based Cohort Study. |
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| المؤلفون: | Barry AR; Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver British Columbia Canada.; Jim Pattison Outpatient Care and Surgery Centre Lower Mainland Pharmacy Services Surrey British Columbia Canada., Helisaz H; GranTAZ Consulting Vancouver British Columbia Canada.; Faculty of Applied Science The University of British Columbia Vancouver British Columbia Canada., Safari A; GranTAZ Consulting Vancouver British Columbia Canada.; School of Mathematics, Statistics and Computer Science, College of Science University of Tehran Tehran Iran., Loewen P; Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver British Columbia Canada.; Centre for Cardiovascular Innovation The University of British Columbia Vancouver British Columbia Canada.; Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences The University of British Columbia Vancouver British Columbia Canada. |
| المصدر: | Journal of the American Heart Association [J Am Heart Assoc] 2024 Jun 18; Vol. 13 (12), pp. e035215. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Wiley-Blackwell |
| مواضيع طبية MeSH: | Coronary Artery Bypass*/adverse effects , Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Angiotensin-Converting Enzyme Inhibitors*/adverse effects , Angiotensin Receptor Antagonists*/therapeutic use , Angiotensin Receptor Antagonists*/adverse effects, Humans ; Male ; Female ; Aged ; Retrospective Studies ; British Columbia/epidemiology ; Middle Aged ; Coronary Artery Disease/surgery ; Coronary Artery Disease/mortality ; Treatment Outcome ; Risk Factors ; Myocardial Infarction/epidemiology ; Time Factors ; Postoperative Complications/epidemiology |
| مستخلص: | Background: The effect of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARBs) on major adverse cardiovascular events (MACE) in patients who undergo coronary artery bypass graft surgery is equivocal. This retrospective, population-based cohort study evaluated effect of exposure to an ACEI/ARB on MACE using linked administrative databases that included all cardiac revascularization procedures, hospitalizations, and prescriptions for the population of British Columbia, Canada. Methods and Results: All adults who underwent coronary artery bypass graft surgery between 2002 and 2020 were eligible. The primary outcome was time to MACE, defined as a composite of all-cause death, myocardial infarction, and ischemic stroke using Cox proportional hazards models with inverse probability treatment weighting. Included were 15 439 patients and 6191 (40%) were prescribed an ACEI/ARB. Mean age was 66 years, 83% were men, and 16% had heart failure (HF). Median exposure time was 40 months. Over the 5-year follow-up, 1623 MACE occurred. Impact of exposure was different for patients with and without HF ( P <0.0001 for interaction). After probability-weighting and adjustment for relevant covariates, exposure to ACEI/ARBs was associated with a lower hazard of MACE in patients with HF at 1 year (hazard ratio, 0.13 [95% CI, 0.09-0.19]) and 5 years (hazard ratio, 0.36 [95% CI, 0.30-0.44]). In patients without HF, ACEI/ARBs had a lower hazard of MACE at 1 year (hazard ratio, 0.35 [95% CI, 0.27-0.46]) and 5 years (hazard ratio, 0.66 [95% CI, 0.58-0.76]). Conclusions: In this population-based study, ACEI/ARBs were associated with a lower hazard of MACE in a cohort of patients post-coronary artery bypass graft surgery irrespective of HF status. |
| فهرسة مساهمة: | Keywords: angiotensin receptor antagonists; angiotensin‐converting enzyme inhibitors; coronary artery bypass; coronary artery disease; medication adherence |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Angiotensin Receptor Antagonists) |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240618 Latest Revision: 20240628 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1161/JAHA.124.035215 |
| PMID: | 38842283 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-9980 |
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| DOI: | 10.1161/JAHA.124.035215 |