دورية أكاديمية
Immunoexpression Patterns of Adhesion Molecules (E-cadherin, β-catenin, CD56) and Cytokeratins (CK19, CK20, HMWCK, CAM5.2) During Hair Development in Human Fetuses Compared With Adults.
| العنوان: | Immunoexpression Patterns of Adhesion Molecules (E-cadherin, β-catenin, CD56) and Cytokeratins (CK19, CK20, HMWCK, CAM5.2) During Hair Development in Human Fetuses Compared With Adults. |
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| المؤلفون: | Zorlu Ö; Department of Dermatology and Venereology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Karabağ S; Department of Pathology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey., Erdoğan KE; Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey., Aksın M; Department of Pathology, Çukurova University Faculty of Medicine, Adana, Turkey; and., Üstün B; Department of Obstetrics and Gynecology, Tekirdağ Namık Kemal University Faculty of Medicine, Tekirdağ, Turkey. |
| المصدر: | The American Journal of dermatopathology [Am J Dermatopathol] 2024 Sep 01; Vol. 46 (9), pp. 572-580. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, Masson Publishing USA. |
| مواضيع طبية MeSH: | beta Catenin*/metabolism , beta Catenin*/analysis , Cadherins*/metabolism , Cadherins*/analysis , Keratins*/analysis , Keratins*/metabolism , Hair Follicle*/metabolism , Immunohistochemistry* , CD56 Antigen*/analysis , CD56 Antigen*/metabolism , Fetus*/metabolism, Humans ; Adult ; Female ; Male ; Middle Aged ; Young Adult ; Antigens, CD/metabolism ; Biomarkers/analysis ; Biomarkers/metabolism |
| مستخلص: | Abstract: Abnormalities in the expression of cytokeratins or adhesion molecules have been associated with hair disorders. The expression patterns of these molecules in the hair follicles of developing human fetuses are not obvious. We aimed to investigate the expression patterns of some cytokeratins and adhesion molecules in the hair follicle of human fetuses and compared them with adults. Forty-eight fetuses of >16 gestational weeks and 22 adult cases with total excisions of benign nevi or cysts were enrolled. The skin samples were taken from both the scalp and back of the fetuses. The histopathologically normal skin areas were evaluated in adults. CK19, CK20, CAM5.2, high-molecular-weight cytokeratin, E-cadherin, β-catenin, and CD56 immunohistochemical stainings were performed. In the fetus group, the staining scores declined in the third trimester but elevated and reached the highest level in adults, except for CD56, which did not stain any adult samples. All stainings were mostly observed in the outer root sheath, except CD56 that stained the perifollicular dermal sheath only in fetuses. E-cadherin, β-catenin, and high-molecular-weight cytokeratin strongly and diffusely stained all adult samples. CAM5.2 and CK19 scores were correlated in fetuses (scalp scores: r s = 0.405, P = 0.004; back scores: r s = 0.422, P = 0.003) and adults (back scores: r s = 0.562, P = 0.046). CD56 negativity indicated the immune-privilege feature of adult hair follicles. As CK19, CAM5.2 may be used to find the regions of stem cells or transient amplifying cells. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
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| المشرفين على المادة: | 0 (beta Catenin) 0 (Cadherins) 68238-35-7 (Keratins) 0 (CTNNB1 protein, human) 0 (CD56 Antigen) 0 (CDH1 protein, human) 0 (NCAM1 protein, human) 0 (Antigens, CD) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240816 Latest Revision: 20240816 |
| رمز التحديث: | 20240816 |
| DOI: | 10.1097/DAD.0000000000002741 |
| PMID: | 38842366 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1533-0311 |
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| DOI: | 10.1097/DAD.0000000000002741 |