دورية أكاديمية
Switching from eltrombopag to hetrombopag in patients with primary immune thrombocytopenia: a post-hoc analysis of a multicenter, randomized phase III trial.
| العنوان: | Switching from eltrombopag to hetrombopag in patients with primary immune thrombocytopenia: a post-hoc analysis of a multicenter, randomized phase III trial. |
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| المؤلفون: | Mei H; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1277 Jiefang Avenue, Wuhan, Hubei, China., Liu X; Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.288 Nanjing Road Heping District, Tianjin, China., Li Y; West China Hospital, Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, China., Zhou H; Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China., Feng Y; The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Gao G; The First Affiliated Hospital of Air Force Medical University, Xi'an, China., Cheng P; The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Huang R; The First Affiliated Hospital of Nanchang University, Nanchang, China., Yang L; The Second Hospital of Shanxi Medical University, Taiyuan, China., Hu J; Fujian Medical University Union Hospital, Fuzhou, China., Hou M; Qilu Hospital, Shandong University, Jinan, China., Yao Y; Baoji Central Hospital, Baoji, China., Liu L; The Second Affiliated Hospital of Air Force Medical University, Xi'an, China., Wang Y; Shaanxi Provincial People's Hospital, Xi'an, China., Wu D; The First Affiliated Hospital of Soochow University, Suzhou, China., Shen X; Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China., Jin J; The First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, China., Luo J; The Second Hospital of Hebei Medical University, Shijiazhuang, China., Zeng Y; First Affiliated Hospital of Kunming Medical University, Kunming, China., Zhou X; Wuxi People's Hospital, Wuxi, China., Xia R; The First Affiliated Hospital of Anhui Medical University, Hefei, China., Jiang Z; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Bai Y; China-Japan Union Hospital of Jilin University, Changchun, China., Niu T; West China Hospital, Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, China. tingniu@sina.com., Yang R; Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.288 Nanjing Road Heping District, Tianjin, China. rcyang65@163.com., Hu Y; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1277 Jiefang Avenue, Wuhan, Hubei, China. dr_huyu@126.com. |
| المصدر: | Annals of hematology [Ann Hematol] 2024 Jul; Vol. 103 (7), pp. 2273-2281. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York : Springer International, c1991- |
| مواضيع طبية MeSH: | Pyrazoles*/therapeutic use , Pyrazoles*/adverse effects , Pyrazoles*/administration & dosage , Benzoates*/therapeutic use , Benzoates*/adverse effects , Benzoates*/administration & dosage , Purpura, Thrombocytopenic, Idiopathic*/drug therapy , Purpura, Thrombocytopenic, Idiopathic*/blood , Hydrazines*/therapeutic use , Hydrazines*/adverse effects , Hydrazines*/administration & dosage , Receptors, Thrombopoietin*/agonists , Pyrazolones*/therapeutic use, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Drug Substitution ; Platelet Count ; Treatment Outcome ; Hydrazones |
| مستخلص: | While studies have explored the feasibility of switching between various thrombopoietin receptor agonists in treating immune thrombocytopenia (ITP), data on the switching from eltrombopag to hetrombopag remains scarce. This post-hoc analysis of a phase III hetrombopag trial aimed to assess the outcomes of ITP patients who switched from eltrombopag to hetrombopag. In the original phase III trial, patients initially randomized to the placebo group were switched to eltrombopag. Those who completed this 14-week eltrombopag were eligible to switch to a 24-week hetrombopag. Treatment response, defined as a platelet count of ≥ 50 × 10 9 /L, and safety were evaluated before and after the switch. Sixty-three patients who completed the 14-week eltrombopag and switched to hetrombopag were included in this post-hoc analysis. Response rates before and after the switch were 66.7% and 88.9%, respectively. Among those with pre-switching platelet counts below 30 × 10 9 /L, eight out of 12 patients (66.7%) responded, while eight out of nine patients (88.9%) with pre-switching platelet counts between 30 × 10 9 /L and 50 × 10 9 /L responded post-switching. Treatment-related adverse events were observed in 50.8% of patients during eltrombopag treatment and 38.1% during hetrombopag treatment. No severe adverse events were noted during hetrombopag treatment. Switching from eltrombopag to hetrombopag in ITP management appears to be effective and well-tolerated. Notably, hetrombopag yielded high response rates, even among patients who had previously shown limited response to eltrombopag. However, these observations need to be confirmed in future trials. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Eltrombopag; Hetrombopag; Immune thrombocytopenia; Switching; Thrombopoietin receptor agonist |
| المشرفين على المادة: | S56D65XJ9G (eltrombopag) 0 (Pyrazoles) 0 (Benzoates) 0 (Hydrazines) 0 (Receptors, Thrombopoietin) 0 (Pyrazolones) 9WGT51BDDL (hetrombopag) 0 (Hydrazones) |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240704 Latest Revision: 20240918 |
| رمز التحديث: | 20240919 |
| مُعرف محوري في PubMed: | PMC11224074 |
| DOI: | 10.1007/s00277-024-05826-5 |
| PMID: | 38842566 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-0584 |
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| DOI: | 10.1007/s00277-024-05826-5 |