دورية أكاديمية
Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia.
العنوان: | Piracetam reduces oxidative stress and mitochondrial function impairment in an in vitro model of vascular dementia. |
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المؤلفون: | Liu J; Department of Neurology, The First Affiliated Hospital of Xi'an Medical University, No.48 FengHao Road(West), Lianhu District, Xi'an City, 710077, Shaanxi Province, China. jliu9667@163.com., Yang N; Department of Neurology, The First Affiliated Hospital of Xi'an Medical University, No.48 FengHao Road(West), Lianhu District, Xi'an City, 710077, Shaanxi Province, China., Wang X; Department of Neurology, The First Affiliated Hospital of Xi'an Medical University, No.48 FengHao Road(West), Lianhu District, Xi'an City, 710077, Shaanxi Province, China., Wang W; Department of Neurology, The First Affiliated Hospital of Xi'an Medical University, No.48 FengHao Road(West), Lianhu District, Xi'an City, 710077, Shaanxi Province, China. |
المصدر: | Experimental brain research [Exp Brain Res] 2024 Aug; Vol. 242 (8), pp. 1841-1850. Date of Electronic Publication: 2024 Jun 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0043312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1106 (Electronic) Linking ISSN: 00144819 NLM ISO Abbreviation: Exp Brain Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
مواضيع طبية MeSH: | Oxidative Stress*/drug effects , Oxidative Stress*/physiology , Dementia, Vascular*/drug therapy , Dementia, Vascular*/metabolism , Piracetam*/pharmacology , Mitochondria*/drug effects , Mitochondria*/metabolism, Humans ; Cell Line, Tumor ; Neuroprotective Agents/pharmacology ; Glucose/metabolism ; Dose-Response Relationship, Drug |
مستخلص: | Vascular dementia (VaD) is the most common cause of dementia in older adults. Due to the lack of effective treatment options, there is an urgent need to find an effective pharmaceutical compound to combat VaD. Piracetam has been reported to improve impaired cognitive function in a variety of conditions in both human and animal models. However, the role and mechanism of Piracetam in VaD remain unclear. Therefore this study aimed to elucidate the effect of Piracetam on a cellular model of VaD in vitro. We found that Piracetam enhanced the growth of OGD-stimulated SH-SY5Y cells. In addition, Piracetam inhibited the oxidative stress of OGD-stimulated SH-SY5Y cells. Further, Piracetam improved mitochondrial function of OGD-stimulated SH-SY5Y cells. Mechanistically, Piracetam inhibited the PI3K/Akt/mTOR pathway in OGD-stimulated SH-SY5Y cells. Collectively, Piracetam improved oxidative stress and mitochondrial dysfunction of OGD-stimulated SH-SY5Y cells through PI3K/Akt/mTOR axis. Hence, Piracetam has the potential to serve as a promising drug of VaD. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: OGD; Oxidative stress; PI3K/Akt/mTOR axis; Piracetam; Vascular dementia (VaD) |
المشرفين على المادة: | ZH516LNZ10 (Piracetam) 0 (Neuroprotective Agents) IY9XDZ35W2 (Glucose) |
تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240716 Latest Revision: 20240716 |
رمز التحديث: | 20240716 |
DOI: | 10.1007/s00221-024-06868-x |
PMID: | 38842755 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1106 |
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DOI: | 10.1007/s00221-024-06868-x |