دورية أكاديمية
Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning.
| العنوان: | Axis formation in annual killifish: Nodal and β-catenin regulate morphogenesis without Huluwa prepatterning. |
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| المؤلفون: | Abitua PB; Genome Sciences, University of Washington, Seattle, WA 98105, USA.; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA., Stump LM; Genome Sciences, University of Washington, Seattle, WA 98105, USA., Aksel DC; Biophysics Program, Harvard University, Cambridge, MA 02138, USA., Schier AF; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.; FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.; Biozentrum, University of Basel, 4051 Basel, Switzerland.; Allen Discovery Center for Cell Lineage Tracing, University of Washington, Seattle, WA 98195, USA. |
| المصدر: | Science (New York, N.Y.) [Science] 2024 Jun 07; Vol. 384 (6700), pp. 1105-1110. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | beta Catenin*/metabolism , Fundulidae*/embryology , Fundulidae*/metabolism , Morphogenesis* , Nodal Protein*/metabolism, Animals ; Blastula/metabolism ; Body Patterning ; Cell Movement ; Cell Nucleus/metabolism ; Germ Layers/metabolism ; Signal Transduction |
| مستخلص: | Axis formation in fish and amphibians typically begins with a prepattern of maternal gene products. Annual killifish embryogenesis, however, challenges prepatterning models as blastomeres disperse and then aggregate to form the germ layers and body axes. We show that huluwa , a prepatterning factor thought to break symmetry by stabilizing β-catenin, is truncated and inactive in Nothobranchius furzeri . Nuclear β-catenin is not selectively stabilized on one side of the blastula but accumulates in cells forming the aggregate. Blocking β-catenin activity or Nodal signaling disrupts aggregate formation and germ layer specification. Nodal signaling coordinates cell migration, establishing an early role for this signaling pathway. These results reveal a surprising departure from established mechanisms of axis formation: Huluwa-mediated prepatterning is dispensable, and β-catenin and Nodal regulate morphogenesis. |
| المشرفين على المادة: | 0 (beta Catenin) 0 (Nodal Protein) |
| SCR Organism: | Nothobranchius furzeri |
| تواريخ الأحداث: | Date Created: 20240606 Date Completed: 20240606 Latest Revision: 20240614 |
| رمز التحديث: | 20240615 |
| DOI: | 10.1126/science.ado7604 |
| PMID: | 38843334 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.ado7604 |