دورية أكاديمية
أعرض في EDS

The ribotoxic stress response drives UV-mediated cell death.

التفاصيل البيبلوغرافية
العنوان: The ribotoxic stress response drives UV-mediated cell death.
المؤلفون: Sinha NK; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., McKenney C; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Yeow ZY; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Li JJ; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Nam KH; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Yaron-Barir TM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Johnson JL; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Huntsman EM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA., Cantley LC; Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Ordureau A; Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: ordureaa@mskcc.org., Regot S; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: sregot@jhmi.edu., Green R; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: ragreen@jhmi.edu.
المصدر: Cell [Cell] 2024 Jul 11; Vol. 187 (14), pp. 3652-3670.e40. Date of Electronic Publication: 2024 Jun 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
مواضيع طبية MeSH: Ultraviolet Rays*/adverse effects , Apoptosis*/radiation effects , DNA Damage*, Phosphorylation/radiation effects ; Humans ; Signal Transduction/radiation effects ; Protein Serine-Threonine Kinases/metabolism ; Stress, Physiological/radiation effects ; Ribosomes/metabolism ; Cell Death/radiation effects
مستخلص: While ultraviolet (UV) radiation damages DNA, eliciting the DNA damage response (DDR), it also damages RNA, triggering transcriptome-wide ribosomal collisions and eliciting a ribotoxic stress response (RSR). However, the relative contributions, timing, and regulation of these pathways in determining cell fate is unclear. Here we use time-resolved phosphoproteomic, chemical-genetic, single-cell imaging, and biochemical approaches to create a chronological atlas of signaling events activated in cells responding to UV damage. We discover that UV-induced apoptosis is mediated by the RSR kinase ZAK and not through the DDR. We identify two negative-feedback modules that regulate ZAK-mediated apoptosis: (1) GCN2 activation limits ribosomal collisions and attenuates ZAK-mediated RSR and (2) ZAK activity leads to phosphodegron autophosphorylation and its subsequent degradation. These events tune ZAK's activity to collision levels to establish regimes of homeostasis, tolerance, and death, revealing its key role as the cellular sentinel for nucleic acid damage.
Competing Interests: Declaration of interests R.G. is a member of the scientific advisory board (SAB) of Alltrna, Initial Therapeutics, and Arrakis Pharmaceuticals, consults for Vertex Pharmaceuticals, Brystol-Myers Squibb (Celgene), Monta Rosa Therapeutics, and Flagship Pioneering, and served on the SAB at Moderna. A.O. received consulting fees from Nine Square Therapeutics Co. L.C.C. is founder and member of the board of directors of Agios Pharmaceuticals; is founder and receives support from Petra Pharmaceuticals; is listed as inventor on a patent (WO2019232403A1, Weill Cornell Medicine); is co-founder and shareholder in Faeth Therapeutics; has equity in and consults for Cell Signaling Technologies, Volastra, Larkspur, and 1 Base Pharmaceuticals; and consults for Loxo-Lilly. T.M.Y.-B. is a co-founder of DeStroke. J.L.J received consulting fees from Scorpion Therapeutics and Volastra Therapeutics. R.G., S.R., N.K.S., and C.M. are listed as inventors on U.S. Provisional Patent Application No. 63/652,824, filed May 29, 2024.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R35 GM133499 United States GM NIGMS NIH HHS; P30 CA008748 United States CA NCI NIH HHS; UL1 TR003098 United States TR NCATS NIH HHS; K99 GM146031 United States GM NIGMS NIH HHS; R37 GM059425 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: DNA damage response; GCN2; UV radiation; ZAK; apoptosis; collisions; phosphoproteomics; ribosomes; ribotoxic stress; signaling
المشرفين على المادة: EC 2.7.11.1 (Protein Serine-Threonine Kinases)
تواريخ الأحداث: Date Created: 20240606 Date Completed: 20240712 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC11246228
DOI: 10.1016/j.cell.2024.05.018
PMID: 38843833
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4172
DOI:10.1016/j.cell.2024.05.018