دورية أكاديمية
أعرض في EDS

Experimental Reconstruction of the Optic Nerve with a Sural Nerve Graft: An in Vivo Experimental Study.

التفاصيل البيبلوغرافية
العنوان: Experimental Reconstruction of the Optic Nerve with a Sural Nerve Graft: An in Vivo Experimental Study.
المؤلفون: Shkarubo AN; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Ogurtsova AA; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Yakupova ZF; Department of Neurosurgery, Peoples FrienSdship University of Russia named after Patrice Lumumba, Moscow, Russia; Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov University, Moscow, Russia., Revishchin AV; Department of Pathomorphology, Institut of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS), Moscow, Russia., Shishkina LV; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Pronin IN; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Chernov IV; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia. Electronic address: ichernov@nsi.ru., Pavlova GV; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia; Department of Pathomorphology, Institut of Higher Nervous Activity and Neurophysiology of RAS (IHNA&NPh RAS), Moscow, Russia., Podoprigora AE; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Shkarubo MA; Department of Neurooncology, Burdenko National Medical Research Center for Neurosurgery, Moscow, Russia., Sinelnikov ME; SINELAB Biomedical Research Centre, Port Jefferson, Minnesota, USA; Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov University, Moscow, Russia., Velichko AJ; Department of Normal Anatomy, Lomonosov Moscow State University, Moscow, Russia., Nikolenko VN; Department of Oncology, Radiotherapy and Reconstructive Surgery, Sechenov University, Moscow, Russia; Department of Normal Anatomy, Lomonosov Moscow State University, Moscow, Russia.
المصدر: World neurosurgery [World Neurosurg] 2024 Aug; Vol. 188, pp. e631-e641. Date of Electronic Publication: 2024 Jun 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101528275 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-8769 (Electronic) Linking ISSN: 18788750 NLM ISO Abbreviation: World Neurosurg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Elsevier
مواضيع طبية MeSH: Optic Nerve*/surgery , Sural Nerve*/transplantation , Nerve Regeneration*/physiology, Animals ; Rabbits ; Optic Nerve Injuries/surgery ; Plastic Surgery Procedures/methods ; Transplantation, Autologous/methods ; Neurosurgical Procedures/methods
مستخلص: Background: Neurosurgical interventions and trauma are common causes of damage to the optic nerve. This determines the relevance of research for solutions aimed at restoration of the nerve's anatomical integrity, electrical conductivity, and subsequently - restoration of its function. Restore a damaged (cut) optic nerve using n. suralis autograft in vivo.
Methods: The experiment involved reconstruction of the optic nerve through injury modulation, graft placement and restored nerve harvest and evaluation. Injury modulation included removal of a fragment of the optic nerve. Autograft harvesting and placement involved resection of a fragment of the sural (sensory) nerve and its subsequent anastomosis in place of the removed fragment of the optic nerve. As an experimental model, a rabbit of the "Burgundy" breed was used. The animal was previously examined for the presence of infectious and other diseases to confirm its health.
Results: Four months post operatively when stimulating the operated right eye, low-amplitude components altered in shape are registered. Thus, signs of mild restoration of electrical conductivity on the treated optic nerve were seen.
Conclusions: Our initial experience shows the technical feasibility of reconstructing the optic nerve using an autograft, the possibility of axonal growth through the graft and, in the future, using this method for direct optic nerve reconstruction, as well as a bypass method for damage to the optic nerve with various tumor diseases of the optic nerve, tumors of the chiasmatic-sellar localization, orbital injuries.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Autograft; Optic nerve; Reconstruction
تواريخ الأحداث: Date Created: 20240606 Date Completed: 20240716 Latest Revision: 20240716
رمز التحديث: 20240716
DOI: 10.1016/j.wneu.2024.06.004
PMID: 38843973
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-8769
DOI:10.1016/j.wneu.2024.06.004