دورية أكاديمية
The value of extracorporeal photopheresis as an immunosuppression-modifying approach in solid organ transplantation: a potential solution to an unmet medical need.
العنوان: | The value of extracorporeal photopheresis as an immunosuppression-modifying approach in solid organ transplantation: a potential solution to an unmet medical need. |
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المؤلفون: | Augusto JF; Department of Nephrology-Dialysis-Transplantation, University Hospital of Angers, Angers, France., Benden C; Faculty of Medicine, University of Zurich, Zurich, Switzerland., Diekmann F; Renal Transplantation Unit, Department of Nephrology and Kidney Transplantation, Hospital Clinic, Barcelona, Spain., Zuckermann A; Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. |
المصدر: | Frontiers in immunology [Front Immunol] 2024 May 23; Vol. 15, pp. 1371554. Date of Electronic Publication: 2024 May 23 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
مواضيع طبية MeSH: | Photopheresis*/methods , Organ Transplantation*/adverse effects , Organ Transplantation*/methods , Graft Rejection*/prevention & control , Graft Rejection*/immunology , Immunosuppression Therapy*/methods, Humans ; Immunosuppressive Agents/therapeutic use ; Immunosuppressive Agents/adverse effects ; Graft Survival |
مستخلص: | Allograft rejection is a critical issue following solid organ transplantation (SOT). Immunosuppressive therapies are crucial in reducing risk of rejection yet are accompanied by several significant side effects, including infection, malignancy, cardiovascular diseases, and nephrotoxicity. There is a current unmet medical need with a lack of effective minimization strategies for these side effects. Extracorporeal photopheresis (ECP) has shown potential as an immunosuppression (IS)-modifying technique in several SOT types, with improvements seen in acute and recurrent rejection, allograft survival, and associated side effects, and could fulfil this unmet need. Through a review of the available literature detailing key areas in which ECP may benefit patients, this review highlights the IS-modifying potential of ECP in the four most common SOT procedures (heart, lung, kidney, and liver transplantation) and highlights existing gaps in data. Current evidence supports the use of ECP for IS modification following SOT, however there is a need for further high-quality research, in particular randomized control trials, in this area. Competing Interests: CB received speaker fees from Mallinckrodt Pharmaceuticals and honoraria for an advisory role from Zambon Pharma. FD received a research grant and speaker fees from Mallinckrodt Pharmaceuticals. AZ received speaker fees from Mallinckrodt Pharmaceuticals, Chiesi and Paragonix and honoraria for an advisory role from Novartis. J-FA received a research grant and speaker fees from Mallinckrodt Pharmaceuticals. The authors declare that this study received funding from Mallinckrodt Pharmaceuticals. The funder(s) had the following involvement in the study: study design, data collection and preparation of the manuscript. (Copyright © 2024 Augusto, Benden, Diekmann and Zuckermann.) |
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فهرسة مساهمة: | Keywords: allograft rejection; calcineurin inhibitors; extracorporeal photopheresis; immunosuppression; solid organ transplantation |
المشرفين على المادة: | 0 (Immunosuppressive Agents) |
تواريخ الأحداث: | Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20240610 |
رمز التحديث: | 20240611 |
مُعرف محوري في PubMed: | PMC11154098 |
DOI: | 10.3389/fimmu.2024.1371554 |
PMID: | 38846942 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-3224 |
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DOI: | 10.3389/fimmu.2024.1371554 |