دورية أكاديمية
Compounds from Natural Products Candidates to Drug for Chikungunya Virus Infection: A Systematic Review.
| العنوان: | Compounds from Natural Products Candidates to Drug for Chikungunya Virus Infection: A Systematic Review. |
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| المؤلفون: | de Mattos Oliveira L; Programa de Pós-Graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Av. Transnordestina, s/n - Feira de Santana, Novo Horizonte - BA, 44036-900, Brazil., Araújo JSC; Programa de Pós-Graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Av. Transnordestina, s/n - Feira de Santana, Novo Horizonte - BA, 44036-900, Brazil., de Andrade KVF; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Feira de Santana, Av. Transnordestina, s/n - Feira de Santana, Novo Horizonte - BA, 44036-900, Brazil., Guerrero ATG; Fundação Oswaldo Cruz (Fiocruz), Mato Grosso do Sul, Brazil., Dos Santos Junior MC; Programa de Pós-Graduação em Biotecnologia, Universidade Estadual de Feira de Santana, Av. Transnordestina, s/n - Feira de Santana, Novo Horizonte - BA, 44036-900, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Feira de Santana, Av. Transnordestina, s/n - Feira de Santana, Novo Horizonte - BA, 44036-900, Brazil. |
| المصدر: | Current drug targets [Curr Drug Targets] 2024 Jun 06. Date of Electronic Publication: 2024 Jun 06. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 100960531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5592 (Electronic) Linking ISSN: 13894501 NLM ISO Abbreviation: Curr Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U. A. E. : Bentham Science Publishers Original Publication: Hilversum, Netherlands ; Boca Raton, FL : Bentham Science Publishers, c2000- |
| مستخلص: | Introduction: Chikungunya fever is a disease caused by infection with the Chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Despite its self-limited character, more than 60% of patients have chronic recurrent arthralgia with debilitating pain that lasts for years. Aim: The objective of this review was to gather and analyze evidence from the literature on potential therapeutic strategies with molecules from natural products for the treatment of Chikungunya fever. Methods: A search was performed for clinical trials, observational studies, in vitro or in vivo, without restriction of the year of publication or language in electronic databases (Medline/PubMed, EMBASE, Google Scholar, The Cochrane Library, LILACS (BVS), clinical trial registries (Clinical Trials.gov), digital libraries from CAPES theses and dissertations (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil) and conference abstracts. A quality assessment of the selected studies was performed using the SYRCLE, RoB2 and SciRAP tools. Results: 42 studies were included, which showed molecules with potential antiviral pharmacological activity or with activity in reducing the joint complications caused by CHIKV infection. Conclusions: Among the molecules found in the survey of references, regarding the class of secondary metabolites, flavonoids stood out and for this reason, the molecules may be promising candidates for future clinical trials. Overall, evidence from in vitro studies was of acceptable quality; in vivo and intervention studies showed a high risk of bias, which is a limitation of these studies. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Biological Products; Chikungunya fever; Chikungunya virus; Drug Discovery; Drug candidates; Secondary metabolites |
| تواريخ الأحداث: | Date Created: 20240607 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| DOI: | 10.2174/0113894501304256240524052446 |
| PMID: | 38847165 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-5592 |
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| DOI: | 10.2174/0113894501304256240524052446 |