دورية أكاديمية
Differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mTOR pathway signaling with adolescent brain maturation.
| العنوان: | Differential effects of moderate chronic ethanol consumption on neurobehavior, white matter glial protein expression, and mTOR pathway signaling with adolescent brain maturation. |
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| المؤلفون: | Yalcin EB; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Lifespan Academic Institutions, The Providence VA Medical Center, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Tong M; Department of Medicine, Rhode Island Hospital, Lifespan Academic Institutions, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Delikkaya B; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Lifespan Academic Institutions, The Providence VA Medical Center, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Pelit W; Department of Chemistry, Brown University, Providence, RI, USA., Yang Y; Biotechnology Graduate Program, Brown University, Providence, RI, USA., de la Monte SM; Department of Pathology and Laboratory Medicine, Rhode Island Hospital, Lifespan Academic Institutions, The Providence VA Medical Center, The Warren Alpert Medical School of Brown University, Providence, RI, USA.; Department of Medicine, Rhode Island Hospital, Lifespan Academic Institutions, The Warren Alpert Medical School of Brown University, Providence, RI, USA.; Departments of Neurology and Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA. |
| المصدر: | The American journal of drug and alcohol abuse [Am J Drug Alcohol Abuse] 2024 Jun 07, pp. 1-25. Date of Electronic Publication: 2024 Jun 07. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 7502510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-9891 (Electronic) Linking ISSN: 00952990 NLM ISO Abbreviation: Am J Drug Alcohol Abuse Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Dekker. |
| مستخلص: | Background: Adolescent brains are highly vulnerable to heavy alcohol exposure. Increased understanding of how alcohol adversely impacts brain maturation may improve treatment outcomes. Objectives: This study characterizes short-term versus long-term effects of ethanol feeding on behavior, frontal lobe glial proteins, and mTOR signaling. Methods: Adolescent rats (8/group) were fed liquid diets containing 26% or 0% ethanol for 2 or 9 weeks, then subjected to novel object recognition (NOR) and open field (OF) tests. Frontal lobes were used for molecular assays. Results: Significant ethanol effects on OF performance occurred in the 2-week model ( p < .0001). Further shifts in OF and NOR performance were unrelated to ethanol exposure in the 9-week models ( p < .05 to p < .0001). Ethanol inhibited MAG1 ( p < .01) and MBP ( p < .0001) after 2 but not 9 weeks. However, both control and ethanol 9-week models had significantly reduced MAG1 ( p < .001-0.0001), MBP ( p < .0001), PDGFRA ( p < .05-0.01), and PLP ( p < .001-0.0001) relative to the 2-week models. GFAP was the only glial protein significantly inhibited by ethanol in both 2- ( p < .01) and 9-week ( p < .05) models. Concerning the mTOR pathway, ethanol reduced IRS-1 ( p < .05) and globally inhibited mTOR ( p < .01 or p < .001) in the 9- but not the 2-week model. Conclusions: Short-term versus long-term ethanol exposures differentially alter neurobehavioral function, glial protein expression, and signaling through IRS-1 and mTOR, which have known roles in myelination during adolescence. These findings suggest that strategies to prevent chronic alcohol-related brain pathology should consider the increased maturation-related vulnerability of adolescent brains. |
| فهرسة مساهمة: | Keywords: Alcohol; adolescence; mTOR; oligodendrocytes; rat model; white matter |
| تواريخ الأحداث: | Date Created: 20240607 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| DOI: | 10.1080/00952990.2024.2355540 |
| PMID: | 38847790 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1097-9891 |
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| DOI: | 10.1080/00952990.2024.2355540 |