دورية أكاديمية
Utility of copeptin in predicting non-pathological postoperative polyuria in patients affected by acromegaly undergoing pituitary neurosurgery.
العنوان: | Utility of copeptin in predicting non-pathological postoperative polyuria in patients affected by acromegaly undergoing pituitary neurosurgery. |
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المؤلفون: | Varaldo E; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy. emanuele.varaldo@unito.it., Prencipe N; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy., Berton AM; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy., Aversa LS; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy., Bioletto F; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy., De Marco R; Skull Base and Pituitary Surgery Unit, 'Città della Salute e della Scienza' University Hospital, Turin, 10126, Italy., Gasco V; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy., Zenga F; Skull Base and Pituitary Surgery Unit, 'Città della Salute e della Scienza' University Hospital, Turin, 10126, Italy., Grottoli S; Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, 10126, Italy. |
المصدر: | Pituitary [Pituitary] 2024 Jun 07. Date of Electronic Publication: 2024 Jun 07. |
Publication Model: | Ahead of Print |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9814578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7403 (Electronic) Linking ISSN: 1386341X NLM ISO Abbreviation: Pituitary Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Norwell, MA : Kluwer Academic Publishers, 1998- |
مستخلص: | Purpose: Copeptin efficiently predicts post-neurosurgical central diabetes insipidus (CDI) in patients with hypothalamic-pituitary lesions, but its role in characterizing changes in diuresis in individuals with acromegaly undergoing neurosurgery remains unexplored. Our study aimed to assess changes in postoperative fluid balance in acromegaly patients and correlate them with both copeptin and growth hormone (GH) levels. Methods: This was a secondary analysis of a prospective study involving 15 acromegaly patients undergoing endoscopic endonasal resection at our University Hospital. Fluid balance was assessed daily, and copeptin and GH levels were evaluated preoperatively (T0), and serially on the morning of the first (T2) and second (T3) postoperative day, with an additional measurement of copeptin one hour post-extubation (T1). Patients with pre-existing or post-neurosurgical CDI were excluded from the analysis. Results: Most patients (11/15) exhibited a negative fluid balance on the second postoperative day, with 4 developing polyuria. Postoperative GH levels did not differ significantly between polyuric and non-polyuric patients, but GH measured at T2 correlated significantly with negative total balance (r = -0.519, p = 0.048). Copeptin levels at T1 were significantly higher in those who developed polyuria (p = 0.013), and a copeptin value > 39.9 pmol/L at T1 showed excellent ability (Sensitivity 100%, Specificity 90.9%, p < 0.001) in predicting postoperative polyuria. Additionally, polyuric patients exhibited a higher T1 / T3 copeptin ratio (p = 0.013) and a negative fluid balance was associated with the remission of acromegaly at 12 months (p = 0.046). Conclusion: The early assessment of copeptin, in addition to facilitating the rapid identification of individuals at increased risk of developing CDI, could also allow the recognition of subjects with a tendency towards non-pathological polyuria in the postoperative setting, at least in individuals affected by acromegaly. (© 2024. The Author(s).) |
التعليقات: | Erratum in: Pituitary. 2024 Jun 28. doi: 10.1007/s11102-024-01419-7. (PMID: 38940860) |
References: | Chanson P, Salenave S (2008) Acromegaly. Orphanet J Rare Dis 3:17. https://doi.org/10.1186/1750-1172-3-17. (PMID: 10.1186/1750-1172-3-17185788662459162) Esposito D, Ragnarsson O, Johannsson G, Olsson DS (2020) Prolonged diagnostic delay in acromegaly is associated with increased morbidity and mortality. Eur J Endocrinol 182:523–531. https://doi.org/10.1530/EJE-20-0019. (PMID: 10.1530/EJE-20-001932213651) Katznelson L, Laws ER Jr, Melmed S et al (2014) Acromegaly: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metabolism 99:3933–3951. https://doi.org/10.1210/jc.2014-2700. (PMID: 10.1210/jc.2014-2700) Colao A, Ferone D, Marzullo P, Lombardi G (2004) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 25:102–152. https://doi.org/10.1210/er.2002-0022. (PMID: 10.1210/er.2002-002214769829) Mercado M, Ramírez-Rentería C (2018) Metabolic complications of Acromegaly. Front Horm Res 49:20–28. https://doi.org/10.1159/000486001. (PMID: 10.1159/00048600129895013) Bioletto F, Barale M, Prencipe N et al (2023) Trabecular bone score as an index of bone fragility in patients with acromegaly: a systematic review and Meta-analysis. Neuroendocrinology 113:395–405. https://doi.org/10.1159/000528199. (PMID: 10.1159/00052819936617407) Tagliafico A, Resmini E, Ferone D, Martinoli C (2011) Musculoskeletal complications of acromegaly: what radiologists should know about early manifestations. Radiol Med 116:781–792. https://doi.org/10.1007/s11547-011-0671-z. (PMID: 10.1007/s11547-011-0671-z21424559) Prencipe N, Motta G, Crespi CM et al (2023) Psychiatric disorders and anger in patients with controlled acromegaly. Minerva Endocrinol (Torino). https://doi.org/10.23736/S2724-6507.23.03960-X. (PMID: 10.23736/S2724-6507.23.03960-X37021924) Cangiano B, Giusti E, Premoli C et al (2022) Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life. Endocrine 77:510–518. https://doi.org/10.1007/s12020-022-03106-8. (PMID: 10.1007/s12020-022-03106-8357792069385810) Ritvonen E, Löyttyniemi E, Jaatinen P et al (2016) Mortality in acromegaly: a 20-year follow-up study. Endocr Relat Cancer 23:469–480. https://doi.org/10.1530/ERC-16-0106. (PMID: 10.1530/ERC-16-010627185871) Kim SY (2015) Diagnosis and treatment of Hypopituitarism. Endocrinol Metab (Seoul) 30:443–455. https://doi.org/10.3803/EnM.2015.30.4.443. (PMID: 10.3803/EnM.2015.30.4.44326790380) Prencipe N, Marinelli L, Varaldo E et al (2023) Isolated anterior pituitary dysfunction in adulthood. Front Endocrinol (Lausanne) 14:1100007. https://doi.org/10.3389/fendo.2023.1100007. (PMID: 10.3389/fendo.2023.110000736967769) Di Perna G, Penner F, Cofano F et al (2021) Skull base reconstruction: a question of flow? A critical analysis of 521 endoscopic endonasal surgeries. PLoS ONE 16:e0245119. https://doi.org/10.1371/journal.pone.0245119. (PMID: 10.1371/journal.pone.0245119337209377959384) Ahmed S, Elsheikh M, Stratton IM et al (1999) Outcome of transphenoidal surgery for acromegaly and its relationship to surgical experience. Clin Endocrinol (Oxf) 50:561–567. https://doi.org/10.1046/j.1365-2265.1999.00760.x. (PMID: 10.1046/j.1365-2265.1999.00760.x10468920) Lamas C, del Pozo C, Villabona C, Neuroendocrinology Group of the SEEN (2014) Clinical guidelines for management of diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion after pituitary surgery. Endocrinol Nutr 61:e15–24. https://doi.org/10.1016/j.endonu.2014.01.005. (PMID: 10.1016/j.endonu.2014.01.00524588923) Morgenthaler NG, Struck J, Alonso C, Bergmann A (2006) Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 52:112–119. https://doi.org/10.1373/clinchem.2005.060038. (PMID: 10.1373/clinchem.2005.06003816269513) Winzeler B, Zweifel C, Nigro N et al (2015) Postoperative copeptin concentration predicts diabetes insipidus after pituitary surgery. J Clin Endocrinol Metab 100:2275–2282. https://doi.org/10.1210/jc.2014-4527. (PMID: 10.1210/jc.2014-452725923040) Tomkins M, Lawless S, Martin-Grace J et al (2022) Diagnosis and management of Central Diabetes Insipidus in adults. J Clin Endocrinol Metab 107:2701–2715. https://doi.org/10.1210/clinem/dgac381. (PMID: 10.1210/clinem/dgac381357719629516129) Berton AM, Gatti F, Penner F et al (2019) Early copeptin determination allows prompt diagnosis of post-neurosurgical central diabetes insipidus. https://doi.org/10.1159/000503145 . Neuroendocrinology. Hensen Johannes H, Anja F, Rudolf et al (2001) Prevalence, predictors and patterns of postoperative polyuria and hyponatraemia in the immediate course after transsphenoidal surgery for pituitary adenomas. Clin Endocrinol 50:431–439. https://doi.org/10.1046/j.1365-2265.1999.00666.x. (PMID: 10.1046/j.1365-2265.1999.00666.x) Zada G, Sivakumar W, Fishback D et al (2010) Significance of postoperative fluid diuresis in patients undergoing transsphenoidal surgery for growth hormone-secreting pituitary adenomas. J Neurosurg 112:744–749. https://doi.org/10.3171/2009.7.JNS09438. (PMID: 10.3171/2009.7.JNS0943819698049) Pennacchietti V, Garzaro M, Grottoli S et al (2016) Three-Dimensional Endoscopic Endonasal Approach and outcomes in Sellar lesions: a single-center experience of 104 cases. World Neurosurg 89:121–125. https://doi.org/10.1016/j.wneu.2016.01.049. (PMID: 10.1016/j.wneu.2016.01.04926836697) Fleseriu M, Hashim IA, Karavitaki N et al (2016) Hormonal replacement in hypopituitarism in adults: an endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 101:3888–3921. https://doi.org/10.1210/jc.2016-2118. (PMID: 10.1210/jc.2016-211827736313) Nemergut EC, Zuo Z, Jane JA, Laws ER (2005) Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients. J Neurosurg 103:448–454. https://doi.org/10.3171/jns.2005.103.3.0448. (PMID: 10.3171/jns.2005.103.3.044816235676) Timper K, Fenske W, Kühn F et al (2015) Diagnostic accuracy of Copeptin in the Differential diagnosis of the polyuria-polydipsia syndrome: a prospective Multicenter Study. J Clin Endocrinol Metab 100:2268–2274. https://doi.org/10.1210/jc.2014-4507. (PMID: 10.1210/jc.2014-450725768671) Ikkos D, Luft R, Sjogren B (1954) Body water and sodium in patients with acromegaly. J Clin Invest 33:989–994. https://doi.org/10.1172/JCI102977. (PMID: 10.1172/JCI10297713174654438531) Chin E, Zhou J, Bondy CA (1992) Renal growth hormone receptor gene expression: relationship to renal insulin-like growth factor system. Endocrinology 131:3061–3066. https://doi.org/10.1210/endo.131.6.1446640. (PMID: 10.1210/endo.131.6.14466401446640) Blazer-Yost BL, Cox M (1988) Insulin-like growth factor 1 stimulates renal epithelial na + transport. Am J Physiol 255:C413–417. https://doi.org/10.1152/ajpcell.1988.255.3.C413. (PMID: 10.1152/ajpcell.1988.255.3.C4132458679) Kamenický P, Mazziotti G, Lombès M et al (2014) Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications. Endocr Rev 35:234–281. https://doi.org/10.1210/er.2013-1071. (PMID: 10.1210/er.2013-107124423979) Johannsson G, Sverrisdóttir YB, Ellegård L et al (2002) GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis. J Clin Endocrinol Metab 87:1743–1749. https://doi.org/10.1210/jcem.87.4.8394. (PMID: 10.1210/jcem.87.4.839411932310) Sharshar T, Carlier R, Blanchard A et al (2002) Depletion of neurohypophyseal content of vasopressin in septic shock. Crit Care Med 30:497–500. https://doi.org/10.1097/00003246-200203000-00001. (PMID: 10.1097/00003246-200203000-0000111990905) García-Álvarez R, Arboleda-Salazar R (2023) Vasopressin in Sepsis and other Shock States: state of the art. J Pers Med 13:1548. https://doi.org/10.3390/jpm13111548. (PMID: 10.3390/jpm131115483800386310672256) Cambria V, Beccuti G, Prencipe N et al (2021) First but not second postoperative day growth hormone assessments as early predictive tests for long-term acromegaly persistence. J Endocrinol Invest 44:2427–2433. https://doi.org/10.1007/s40618-021-01553-0. (PMID: 10.1007/s40618-021-01553-0338379208502138) |
فهرسة مساهمة: | Keywords: Arginine vasopressin; CT-proAVP; Central diabetes insipidus; Fluid balance; GH; Growth hormone |
تواريخ الأحداث: | Date Created: 20240607 Latest Revision: 20240701 |
رمز التحديث: | 20240701 |
DOI: | 10.1007/s11102-024-01407-x |
PMID: | 38847919 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7403 |
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DOI: | 10.1007/s11102-024-01407-x |