دورية أكاديمية
Glutathione-responsive CD-MOFs co-loading honokiol and indocyanine green biomimetic active targeting to enhance photochemotherapy for breast cancer.
| العنوان: | Glutathione-responsive CD-MOFs co-loading honokiol and indocyanine green biomimetic active targeting to enhance photochemotherapy for breast cancer. |
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| المؤلفون: | He Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Guo J; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Ding H; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Lin M; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Wu Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., He Z; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China., Wang Z; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Xia Q; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhu C; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhang Y; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: analysisdrug@126.com., Feng N; School of Parmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: npfeng@shutcm.edu.cn. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2024 Jul 20; Vol. 660, pp. 124310. Date of Electronic Publication: 2024 Jun 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Indocyanine Green*/administration & dosage , Indocyanine Green*/chemistry , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Photochemotherapy*/methods , Biphenyl Compounds*/administration & dosage , Biphenyl Compounds*/chemistry , Metal-Organic Frameworks*/chemistry , Glutathione*/metabolism , Lignans*/administration & dosage , Lignans*/chemistry , Lignans*/pharmacology , Drug Liberation*, Animals ; Female ; Humans ; MCF-7 Cells ; Mice, Inbred BALB C ; Cyclodextrins/chemistry ; Mice ; Apoptosis/drug effects ; Nanoparticles/chemistry ; Nanoparticles/administration & dosage ; Drug Delivery Systems/methods ; Reactive Oxygen Species/metabolism ; Mice, Nude ; Drug Carriers/chemistry ; Allyl Compounds ; Phenols |
| مستخلص: | Breast cancer has now replaced lung cancer as the most prevalent malignant tumor worldwide, posing a serious health risk to women. We have recently designed a promising option strategy for the treatment of breast cancer. In this work, cyclodextrin metal-organic frameworks with high drug-carrying properties were endo-crosslinked by 3,3'dithiodipropionyl chloride to form cubic phase gel nanoparticles, which were drug-loaded and then coated by MCF-7 cell membranes. After intravenous injection, this multifunctional nanomedicine achieved dramatically homologous targeting co-delivery of honokiol and indocyanine green to the breast tumor. Further, the disulfide bonds in the nanostructures achieved glutathione-responsive drug release, induced tumor cells to produce reactive oxygen species and promoted apoptosis, resulting in tumor necrosis, and at the same time, inhibited Ki67 protein expression, which enhanced photochemotherapy, and resulted in a 94.08 % in vivo tumor suppression rate in transplanted tumor-bearing mice. Thereby, this nanomimetic co-delivery system may have a place in breast cancer therapy due to its simple fabrication process, excellent biocompatibility, efficient targeted delivery of insoluble drugs, and enhanced photochemotherapy. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cell membrane; Disulfide bond; Internal crosslink; MCF-7; Nanogel; Photothermal |
| المشرفين على المادة: | IX6J1063HV (Indocyanine Green) 11513CCO0N (honokiol) 0 (Biphenyl Compounds) 0 (Metal-Organic Frameworks) GAN16C9B8O (Glutathione) 0 (Lignans) 0 (Cyclodextrins) 0 (Reactive Oxygen Species) 0 (Drug Carriers) 0 (Allyl Compounds) 0 (Phenols) |
| تواريخ الأحداث: | Date Created: 20240607 Date Completed: 20240712 Latest Revision: 20240712 |
| رمز التحديث: | 20240713 |
| DOI: | 10.1016/j.ijpharm.2024.124310 |
| PMID: | 38848796 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2024.124310 |