دورية أكاديمية
أعرض في EDS

Hyperoside reduced particulate matter 2.5-induced endoplasmic reticulum stress and senescence in skin cells.

التفاصيل البيبلوغرافية
العنوان: Hyperoside reduced particulate matter 2.5-induced endoplasmic reticulum stress and senescence in skin cells.
المؤلفون: Fernando PDSM; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea., Piao MJ; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea., Herath HMUL; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea., Kang KA; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea., Hyun CL; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Kim ET; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Koh YS; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea., Hyun JW; Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea; Department of Biochemistry, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea. Electronic address: jinwonh@jejunu.ac.kr.
المصدر: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Aug; Vol. 99, pp. 105870. Date of Electronic Publication: 2024 Jun 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3177 (Electronic) Linking ISSN: 08872333 NLM ISO Abbreviation: Toxicol In Vitro Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford ; New York : Pergamon Press, c1987-
مواضيع طبية MeSH: Endoplasmic Reticulum Stress*/drug effects , Particulate Matter*/toxicity , Cellular Senescence*/drug effects , Quercetin*/pharmacology , Quercetin*/analogs & derivatives , Keratinocytes*/drug effects, Humans ; Cell Line ; Cell Proliferation/drug effects ; Cell Cycle/drug effects ; HaCaT Cells ; Antioxidants/pharmacology ; Skin/drug effects ; Skin/metabolism ; Skin/cytology
مستخلص: Particulate matter 2.5 (PM 2.5 ) causes skin aging, inflammation, and impaired skin homeostasis. Hyperoside, a flavanol glycoside, has been proposed to reduce the risk of diseases caused by oxidative stress. This study evaluated the cytoprotective potential of hyperoside against PM 2.5 -induced skin cell damage. Cultured human HaCaT keratinocytes were pretreated with hyperoside and treated with PM 2.5 . Initially, the cytoprotective and antioxidant ability of hyperoside against PM 2.5 was evaluated. Western blotting was further employed to investigate endoplasmic reticulum (ER) stress and cellular senescence and for evaluation of cell cycle regulation-related proteins. Hyperoside inhibited PM 2.5 -mediated ER stress as well as mitochondrial damage. Colony formation assessment confirmed that PM 2.5 -impaired cell proliferation was restored by hyperoside. Moreover, hyperoside reduced the activation of PM 2.5 -induced ER stress-related proteins, such as protein kinase R-like ER kinase, cleaved activating transcription factor 6, and inositol-requiring enzyme 1. Hyperoside promoted cell cycle progression in the G 0 /G 1 phase by upregulating the PM 2.5 -impaired cell cycle regulatory proteins. Hyperoside significantly reduced the expression of PM 2.5 -induced senescence-associated β-galactosidase and matrix metalloproteinases (MMPs), such as MMP-1 and MMP-9. Overall, hyperoside ameliorated PM 2.5 -impaired cell proliferation, ER stress, and cellular senescence, offering potential therapeutic implications for mitigating the adverse effects of environmental pollutants on skin health.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Cell cycle arrest; ER stress; Hyperoside; PM(2.5); Senescence
المشرفين على المادة: 0 (Particulate Matter)
9IKM0I5T1E (Quercetin)
8O1CR18L82 (hyperoside)
0 (Antioxidants)
تواريخ الأحداث: Date Created: 20240607 Date Completed: 20240721 Latest Revision: 20240721
رمز التحديث: 20240722
DOI: 10.1016/j.tiv.2024.105870
PMID: 38848825
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-3177
DOI:10.1016/j.tiv.2024.105870