دورية أكاديمية
Anthropometric traits and risk of multiple myeloma: differences by race, sex and diagnostic clinical features.
| العنوان: | Anthropometric traits and risk of multiple myeloma: differences by race, sex and diagnostic clinical features. |
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| المؤلفون: | Arnold KD; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Ong KL; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Ravi G; Division of Hematology and Medical Oncology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Cutshall H; Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA., Purnell K; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Wessel MC; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Godby KN; Division of Hematology and Medical Oncology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Bal S; Division of Hematology and Medical Oncology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Giri S; Division of Hematology and Medical Oncology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Rogers LQ; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; Division of Preventive Medicine, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Demark-Wahnefried W; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; Department of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Davies FE; Perlmutter Comprehensive Cancer Center, Langone Medical Center, New York University, New York, NY, 10021, USA., Costa LJ; Division of Hematology and Medical Oncology, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA., Morgan GJ; Perlmutter Comprehensive Cancer Center, Langone Medical Center, New York University, New York, NY, 10021, USA., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA., Brown EE; Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. elizabethbrown@uabmc.edu.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. elizabethbrown@uabmc.edu. |
| المصدر: | British journal of cancer [Br J Cancer] 2024 Jun 07. Date of Electronic Publication: 2024 Jun 07. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK Original Publication: London, Lewis. |
| مستخلص: | Background: Obesity is an established modifiable risk factor for multiple myeloma (MM). However, associations of obesity and MM risk in Black populations, for whom obesity and MM are more common, is less clear. Methods: Using participants enrolled in the Integrative Molecular And Genetic Epidemiology study, we evaluated the association of anthropometric traits with MM risk overall, stratified by race and sex. Among cases, we assessed the association of BMI with the presence of myeloma-defining events. Results: We observed an 18% increase in MM risk for every 5 kg/m 2 increase in usual adult BMI. Participants with severe obesity (BMI ≥ 40 kg/m 2 ) had the highest risk compared to those with a normal usual adult BMI (18.5-24.9 kg/m 2 ; OR = 1.87, 95% CI 1.25-2.80), particularly among Black men (OR = 3.94, 95% CI 0.90-17.36). Furthermore, MM cases with overweight/obesity (BMI ≥ 25 kg/m 2 ) were more likely to present at diagnosis with low renal function (OR = 1.62, 95% CI 1.09-2.40), deletion 13q (OR = 1.73, 95% CI 1.08-2.76) and lytic lesions or compression fractures (OR = 2.39, 95% CI 0.82-7.01) and less likely to present with severe diffuse osteopenia (OR = 0.51, 95% CI 0.31-0.81). Conclusions: Findings underscore the importance of obesity as a modifiable risk factor for MM, particularly in high-risk populations, and for the clinical presentation of disease. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | U01 CA249955 United States CA NCI NIH HHS; R01 CA186646 United States CA NCI NIH HHS; R21 CA182861 United States CA NCI NIH HHS; R21 CA155951 United States CA NCI NIH HHS; IRG60-001-47 American Cancer Society (American Cancer Society, Inc.) |
| تواريخ الأحداث: | Date Created: 20240607 Latest Revision: 20240607 |
| رمز التحديث: | 20240608 |
| DOI: | 10.1038/s41416-024-02723-6 |
| PMID: | 38849476 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-1827 |
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| DOI: | 10.1038/s41416-024-02723-6 |