Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study.

التفاصيل البيبلوغرافية
العنوان:	Preparing for future pandemics: frailty associates with mortality in hospitalised older people during the entire COVID-19 pandemic, a Dutch multicentre cohort study.
المؤلفون:	van Raaij BFM; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands. b.f.m.van_raaij@lumc.nl.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands. b.f.m.van_raaij@lumc.nl., Noordam R; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands., Smits RAL; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands., van der Klei VMGTH; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands., Jansen SWM; Department of Geriatric Medicine, Catharina Hospital, Eindhoven, The Netherlands., van der Linden CMJ; Department of Geriatric Medicine, Catharina Hospital, Eindhoven, The Netherlands., Polinder-Bos HA; Division of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Minnema J; Division of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Tap L; Division of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., van der Bol JM; Department of Geriatric Medicine, Reinier de Graaf Hospital, Delft, The Netherlands., van de Glind EMM; Department of Geriatric Medicine, Alrijne Hospital, Leiderdorp, The Netherlands., Willems HC; Department of Internal Medicine and Geriatrics, Amsterdam University Medical Center, Amsterdam, The Netherlands., van Deudekom FJA; Department of Geriatric Medicine, OLVG Hospital, Amsterdam, The Netherlands., Ruiter R; Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands., van Munster BC; Department of Geriatric Medicine, University Medical Center Groningen, Groningen, The Netherlands., Robben SHM; Department of Geriatric Medicine, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands., Schouten HJ; Department of Geriatric Medicine, Gelre Hospital, Apeldoorn, Zutphen, The Netherlands., Barten DG; Department of Emergency Medicine, VieCuri Medical Center, Venlo, The Netherlands., Lucke JA; Department of Emergency Medicine, Spaarne Gasthuis, Haarlem, the Netherlands., Peeters G; Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Trompet S; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands., Drewes YM; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands., van den Bos F; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands., Gussekloo J; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Mooijaart SP; Department of Internal Medicine, Section of Geriatrics and Gerontology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.; LUMC Center of Medicine for Older People, Leiden University Medical Center, Leiden, The Netherlands.
مؤلفون مشاركون:	COOP study group
المصدر:	European geriatric medicine [Eur Geriatr Med] 2024 Jun 07. Date of Electronic Publication: 2024 Jun 07.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101533694 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1878-7649 (Print) Linking ISSN: 18787649 NLM ISO Abbreviation: Eur Geriatr Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2018- : Cham : Springer International Publishing Original Publication: Issy-les-Moulineaux, Paris : Elsevier Masson SAS
مستخلص:	Purpose: Viral mutations and improved prevention or treatment options may have changed the association of frailty with mortality throughout the COVID-19 pandemic. We investigated how associations of frailty with in-hospital mortality changed throughout the pandemic in older people hospitalised for COVID-19. Methods: The COVID-OLD study included COVID-19 patients aged ≥ 70 years hospitalised during the first (early 2020), second (late 2020), third (late 2021) or fourth wave (early 2022). Based on the clinical frailty scale, patients were categorised as fit (1-3), pre-frail (4-5) or frail (6-9). Associations of frailty with in-hospital mortality were assessed with pairwise comparisons with fit as reference category and modelled using binary logistic regression adjusted for age and sex. Results: This study included 2362 patients (mean age 79.7 years, 60% men). In the first wave, in-hospital mortality was 46% in patients with frailty and 27% in fit patients. In-hospital mortality decreased in each subsequent wave to 25% in patients with frailty and 11% in fit patients in the fourth wave. After adjustments, an overall higher risk of in-hospital mortality was found in frail (OR 2.26, 95% CI: 1.66-3.07) and pre-frail (OR 1.73, 95% CI: 1.27-2.35) patients compared to fit patients, which did not change over time (p for interaction = 0.74). Conclusions: Frailty remained associated with a higher risk of in-hospital mortality throughout the entire COVID-19 pandemic, although overall in-hospital mortality rates decreased. Frailty therefore remains a relevant risk factor in all stages of a pandemic and is important to consider in prevention and treatment guidelines for future pandemics. (© 2024. The Author(s).)
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معلومات مُعتمدة:	10430102110005 Netherlands ZONMW_ ZonMw
فهرسة مساهمة:	Investigator: SP Mooijaart; HA Polinder-Bos; KGM Moons; M Smeden; G Peeters; RJF Melis; PJM Elders; J Festen Keywords: COVID-19; Frailty; In-hospital mortality
تواريخ الأحداث:	Date Created: 20240607 Latest Revision: 20240607
رمز التحديث:	20240608
DOI:	10.1007/s41999-024-01001-1
PMID:	38849648
قاعدة البيانات:	MEDLINE

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تدمد:	1878-7649
DOI:	10.1007/s41999-024-01001-1