دورية أكاديمية
أعرض في EDS

Associations of sex-related and thyroid-related hormones with risk of metabolic dysfunction-associated fatty liver disease in T2DM patients.

التفاصيل البيبلوغرافية
العنوان: Associations of sex-related and thyroid-related hormones with risk of metabolic dysfunction-associated fatty liver disease in T2DM patients.
المؤلفون: Lu W; Department of Gynecology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China.; Xiamen Clinical Research Center for Cancer Therapy, Xiamen, China., Li S; Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China., Li Y; School of Mechanics and Civil Engineering, China University of Mining & Technology- Beijing, Beijing, China., Zhou J; Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China., Wang K; Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China., Chen N; Department of Endocrinology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, China. chen.ning@zsxmhospital.com., Li Z; Epidemiology Research Unit Translational Medicine Research Center, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, No.55 Zhenhai Road, Xiamen, 361003, China. zhibinli33@hotmail.com.
المصدر: BMC endocrine disorders [BMC Endocr Disord] 2024 Jun 07; Vol. 24 (1), pp. 84. Date of Electronic Publication: 2024 Jun 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088676 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6823 (Electronic) Linking ISSN: 14726823 NLM ISO Abbreviation: BMC Endocr Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/blood , Diabetes Mellitus, Type 2*/epidemiology , Thyroid Hormones*/blood, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; China/epidemiology ; Risk Factors ; Aged ; Gonadal Steroid Hormones/blood ; Non-alcoholic Fatty Liver Disease/blood ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/complications ; Biomarkers/blood ; Adult ; Follow-Up Studies ; Sex Factors ; Prognosis ; Fatty Liver/blood ; Fatty Liver/epidemiology ; Fatty Liver/etiology
مستخلص: Background: We aimed to examine sex-specific associations between sex- and thyroid-related hormones and the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with type 2 diabetes mellitus (T2DM).
Methods: Cross-sectional analyses of baseline information from an ongoing cohort of 432 T2DM patients (185 women and 247 men) in Xiamen, China were conducted. Plasma sex-related hormones, including estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), progesterone, and total testosterone (TT), and thyroid-related hormones, including free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and parathyroid hormone (PTH), were measured using chemiluminescent immunoassays. MAFLD was defined as the presence of hepatic steatosis (diagnosed by either hepatic ultrasonography scanning or fatty liver index (FLI) score > 60) since all subjects had T2DM in the present study.
Results: Prevalence of MAFLD was 65.6% in men and 61.1% in women with T2DM (P = 0.335). For men, those with MAFLD showed significantly decreased levels of FSH (median (interquartile range (IQR)):7.2 (4.9-11.1) vs. 9.8 (7.1-12.4) mIU/ml) and TT (13.2 (10.4-16.5) vs. 16.7 (12.8-21.6) nmol/L) as well as increased level of FT3 (mean ± standard deviation (SD):4.63 ± 0.68 vs. 4.39 ± 0.85 pmol/L) than those without MAFLD (all p-values < 0.05). After adjusting for potential confounding factors, FSH and LH were negative, while progesterone was positively associated with the risk of MAFLD in men, and the adjusted odds ratios (ORs) (95% confidence intervals (CIs)) were 0.919 (0.856-0.986), 0.888 (0.802-0.983), and 8.069 (2.019-32.258) (all p-values < 0.05), respectively. In women, there was no statistically significant association between sex- or thyroid-related hormones and the risk of MAFLD.
Conclusion: FSH and LH levels were negative, whereas progesterone was positively associated with the risk of MAFLD in men with T2DM. Screening for MAFLD and monitoring sex-related hormones are important for T2DM patients, especially in men.
(© 2024. The Author(s).)
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معلومات مُعتمدة: No. 3502Z20209048 and No. 3502Z20209053 Guiding Project on Medicine and Health in Xiamen, China; No. 3502Z20209048 and No. 3502Z20209053 Guiding Project on Medicine and Health in Xiamen, China; No. 2022J011426 Fujian Province Nature Science Foundations, China
فهرسة مساهمة: Keywords: Diabetes; Follicle-stimulating hormone; MAFLD; Sex hormone; Thyroid hormone
المشرفين على المادة: 0 (Thyroid Hormones)
0 (Gonadal Steroid Hormones)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240607 Date Completed: 20240608 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC11161932
DOI: 10.1186/s12902-024-01618-0
PMID: 38849804
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6823
DOI:10.1186/s12902-024-01618-0