دورية أكاديمية
A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study.
| العنوان: | A bidirectional autoimmune cluster between vitiligo and rheumatoid arthritis: a large-scale population-based study. |
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| المؤلفون: | Cohen NT; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel., Schonmann Y; Medical School for International Health, Ben Gurion University, Negev Be'er Sheva, Israel.; Clalit Health Services, Tel-Aviv, Israel., Kridin K; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. dr_kridin@hotmail.com.; Clalit Health Services, Tel-Aviv, Israel. dr_kridin@hotmail.com.; Unit of Dermatology and Skin Research Laboratory, Galilee Medical Center, Nahariya, Israel. dr_kridin@hotmail.com.; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany. dr_kridin@hotmail.com. |
| المصدر: | Archives of dermatological research [Arch Dermatol Res] 2024 Jun 08; Vol. 316 (7), pp. 366. Date of Electronic Publication: 2024 Jun 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer Verlag |
| مواضيع طبية MeSH: | Vitiligo*/epidemiology , Arthritis, Rheumatoid*/epidemiology , Arthritis, Rheumatoid*/complications, Humans ; Female ; Male ; Middle Aged ; Case-Control Studies ; Adult ; Incidence ; Aged ; Taiwan/epidemiology ; Risk Factors ; Databases, Factual |
| مستخلص: | A knowledge gap exists regarding the association between vitiligo and rheumatoid arthritis (RA) due to the absence of large-scale cohort studies designed to investigate this association. To investigate the bidirectional epidemiological association between vitiligo and RA. A population-based study was conducted using Clalit Health Services (CHS) database (2002-2019) using both a cohort study and a case-control study design. Adjusted hazard ratio (HR) and odds ratio (OR) were calculated by multivariate Cox and logistic regressions, respectively. Overall, 20,851 vitiligo patients and 102,475 controls were included. The incidence of new-onset RA was 4.1 (95% CI 3.0-5.4) and 2.9 (95% CI 2.4-3.3) cases per 10,000 person-years among patients with vitiligo and controls, respectively. Patients with vitiligo had a significantly increased risk of developing new-onset RA (adjusted HR, 1.44; 95% confidence interval [CI], 1.02-2.02, P = 0.036). The likelihood of having vitiligo was significantly elevated after a preexisting diagnosis of RA (adjusted OR, 1.67; 95% CI, 1.38-2.03; P < 0.001). Relative to the remaining patients with vitiligo, those with vitiligo and comorbid RA demonstrated an elevated risk of all-cause mortality (adjusted HR, 1.61; 95% CI, 1.03-2.51; P = 0.037). Our study confirms the bidirectional association between vitiligo and RA. Physicians treating patients with vitiligo should be aware of the association in clinical practice. (© 2024. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Case-control study; Cohort study; Rheumatoid arthritis; Vitiligo |
| تواريخ الأحداث: | Date Created: 20240608 Date Completed: 20240608 Latest Revision: 20240611 |
| رمز التحديث: | 20240611 |
| مُعرف محوري في PubMed: | PMC11162386 |
| DOI: | 10.1007/s00403-024-02965-7 |
| PMID: | 38850409 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-069X |
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| DOI: | 10.1007/s00403-024-02965-7 |