دورية أكاديمية
أعرض في EDS

A spatiotemporal map of co-receptor signaling networks underlying B cell activation.

التفاصيل البيبلوغرافية
العنوان: A spatiotemporal map of co-receptor signaling networks underlying B cell activation.
المؤلفون: Susa KJ; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: katherine.susa@ucsf.edu., Bradshaw GA; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Eisert RJ; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Schilling CM; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Kalocsay M; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: mkalocsay@mdanderson.org., Blacklow SC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: stephen_blacklow@hms.harvard.edu., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: andrew_kruse@hms.harvard.edu.
المصدر: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114332. Date of Electronic Publication: 2024 Jun 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Signal Transduction* , B-Lymphocytes*/metabolism , B-Lymphocytes*/immunology , Receptors, Antigen, B-Cell*/metabolism , Lymphocyte Activation*, Humans ; Antigens, CD19/metabolism ; Cell Line, Tumor ; Oxidation-Reduction
مستخلص: The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with quantitative mass spectrometry to track co-receptor signaling dynamics in Raji cells from 10 s to 2 h after BCR stimulation. This approach enables tracking of 2,814 proximity-labeled proteins and 1,394 phosphosites and provides an unbiased and quantitative molecular map of proteins recruited to the vicinity of CD19, the signaling subunit of the co-receptor complex. We detail the recruitment kinetics of signaling effectors to CD19 and identify previously uncharacterized mediators of B cell activation. We show that the glutamate transporter SLC1A1 is responsible for mediating rapid metabolic reprogramming and for maintaining redox homeostasis during B cell activation. This study provides a comprehensive map of BCR signaling and a rich resource for uncovering the complex signaling networks that regulate activation.
Competing Interests: Declaration of interests A.C.K. is a co-founder and consultant for biotechnology companies Tectonic Therapeutic Inc. and Seismic Therapeutic Inc., as well as for the Institute for Protein Innovation, a non-profit research institute. S.C.B. is on the scientific advisory board for and receives funding from Erasca, Inc. for an unrelated project; is an advisor to MPM Capital; and is a consultant for IFM, Scorpion Therapeutics, Odyssey Therapeutics, Droia Ventures, and Ayala Pharmaceuticals for unrelated projects.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
التعليقات: Update of: bioRxiv. 2023 Mar 21:2023.03.17.533227. doi: 10.1101/2023.03.17.533227. (PMID: 36993395)
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معلومات مُعتمدة: DP5 OD036136 United States OD NIH HHS; F31 HL147459 United States HL NHLBI NIH HHS; R01 AI172846 United States AI NIAID NIH HHS; R35 CA220340 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: B cell signaling; CP: Immunology; co-receptor; phosphoproteomics; proteomics; proximity labeling
المشرفين على المادة: 0 (Receptors, Antigen, B-Cell)
0 (Antigens, CD19)
تواريخ الأحداث: Date Created: 20240608 Date Completed: 20240701 Latest Revision: 20240719
رمز التحديث: 20240719
مُعرف محوري في PubMed: PMC11256977
DOI: 10.1016/j.celrep.2024.114332
PMID: 38850533
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2024.114332