دورية أكاديمية
أعرض في EDS

White matter integrity and functional connectivity of the default mode network in acute stroke are associated with cognitive outcome three months post-stroke.

التفاصيل البيبلوغرافية
العنوان: White matter integrity and functional connectivity of the default mode network in acute stroke are associated with cognitive outcome three months post-stroke.
المؤلفون: Fruhwirth V; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria; Institute of Psychology, Department of Biological Psychology, University of Graz, Graz, Austria., Berger L; Institute of Psychology, Department of Neuropsychology - Neuroimaging, University of Graz, Graz, Austria., Gattringer T; Department of Neurology, Medical University of Graz, Graz, Austria; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Fandler-Höfler S; Department of Neurology, Medical University of Graz, Graz, Austria., Kneihsl M; Department of Neurology, Medical University of Graz, Graz, Austria., Eppinger S; Department of Neurology, Medical University of Graz, Graz, Austria., Ropele S; Department of Neurology, Medical University of Graz, Graz, Austria., Fink A; Institute of Psychology, Department of Biological Psychology, University of Graz, Graz, Austria., Deutschmann H; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Reishofer G; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Enzinger C; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Pinter D; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria. Electronic address: daniela.pinter@medunigraz.at.
المصدر: Journal of the neurological sciences [J Neurol Sci] 2024 Jul 15; Vol. 462, pp. 123071. Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, <19 ->
مواضيع طبية MeSH: White Matter*/diagnostic imaging , White Matter*/pathology , Stroke*/diagnostic imaging , Stroke*/complications , Stroke*/physiopathology , Magnetic Resonance Imaging* , Default Mode Network*/diagnostic imaging , Default Mode Network*/physiopathology, Humans ; Female ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Adult ; Longitudinal Studies ; Neuropsychological Tests ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/physiopathology ; Young Adult ; Adolescent ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain/pathology ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology
مستخلص: Background: Knowledge about factors that are associated with post-stroke cognitive outcome is important to identify patients with high risk for impairment. We therefore investigated the associations of white matter integrity and functional connectivity (FC) within the brain's default-mode network (DMN) in acute stroke patients with cognitive outcome three months post-stroke.
Methods: Patients aged between 18 and 85 years with an acute symptomatic MRI-proven unilateral ischemic middle cerebral artery infarction, who had received reperfusion therapy, were invited to participate in this longitudinal study. All patients underwent brain MRI within 24-72 h after symptom onset, and participated in a neuropsychological assessment three months post-stroke. We performed hierarchical regression analyses to explore the incremental value of baseline white matter integrity and FC beyond demographic, clinical, and macrostructural information for cognitive outcome.
Results: The study cohort comprised 34 patients (mean age: 64 ± 12 years, 35% female). The initial median National Institutes of Health Stroke Scale (NIHSS) score was 10, and significantly improved three months post-stroke to a median NIHSS = 1 (p < .001). Nonetheless, 50% of patients showed cognitive impairment three months post-stroke. FC of the non-lesioned anterior cingulate cortex of the affected hemisphere explained 15% of incremental variance for processing speed (p = .007), and fractional anisotropy of the non-lesioned cingulum of the affected hemisphere explained 13% of incremental variance for cognitive flexibility (p = .033).
Conclusions: White matter integrity and functional MRI markers of the DMN in acute stroke explain incremental variance for post-stroke cognitive outcome beyond demographic, clinical, and macrostructural information.
Competing Interests: Declaration of competing interest The authors declare no financial or other conflicts of interest that relate to the research covered in this article.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Cognition; Default mode network; Longitudinal; MRI; Stroke
تواريخ الأحداث: Date Created: 20240608 Date Completed: 20240710 Latest Revision: 20240710
رمز التحديث: 20240711
DOI: 10.1016/j.jns.2024.123071
PMID: 38850772
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5883
DOI:10.1016/j.jns.2024.123071