دورية أكاديمية
White matter integrity and functional connectivity of the default mode network in acute stroke are associated with cognitive outcome three months post-stroke.
العنوان: | White matter integrity and functional connectivity of the default mode network in acute stroke are associated with cognitive outcome three months post-stroke. |
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المؤلفون: | Fruhwirth V; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria; Institute of Psychology, Department of Biological Psychology, University of Graz, Graz, Austria., Berger L; Institute of Psychology, Department of Neuropsychology - Neuroimaging, University of Graz, Graz, Austria., Gattringer T; Department of Neurology, Medical University of Graz, Graz, Austria; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Fandler-Höfler S; Department of Neurology, Medical University of Graz, Graz, Austria., Kneihsl M; Department of Neurology, Medical University of Graz, Graz, Austria., Eppinger S; Department of Neurology, Medical University of Graz, Graz, Austria., Ropele S; Department of Neurology, Medical University of Graz, Graz, Austria., Fink A; Institute of Psychology, Department of Biological Psychology, University of Graz, Graz, Austria., Deutschmann H; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Reishofer G; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Enzinger C; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria; Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, Graz, Austria., Pinter D; Department of Neurology, Medical University of Graz, Graz, Austria; Department of Neurology, Research Unit for Neuronal Plasticity and Repair, Medical University of Graz, Graz, Austria. Electronic address: daniela.pinter@medunigraz.at. |
المصدر: | Journal of the neurological sciences [J Neurol Sci] 2024 Jul 15; Vol. 462, pp. 123071. Date of Electronic Publication: 2024 May 31. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, <19 -> |
مواضيع طبية MeSH: | White Matter*/diagnostic imaging , White Matter*/pathology , Stroke*/diagnostic imaging , Stroke*/complications , Stroke*/physiopathology , Magnetic Resonance Imaging* , Default Mode Network*/diagnostic imaging , Default Mode Network*/physiopathology, Humans ; Female ; Male ; Middle Aged ; Aged ; Aged, 80 and over ; Adult ; Longitudinal Studies ; Neuropsychological Tests ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/physiopathology ; Young Adult ; Adolescent ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain/pathology ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology |
مستخلص: | Background: Knowledge about factors that are associated with post-stroke cognitive outcome is important to identify patients with high risk for impairment. We therefore investigated the associations of white matter integrity and functional connectivity (FC) within the brain's default-mode network (DMN) in acute stroke patients with cognitive outcome three months post-stroke. Methods: Patients aged between 18 and 85 years with an acute symptomatic MRI-proven unilateral ischemic middle cerebral artery infarction, who had received reperfusion therapy, were invited to participate in this longitudinal study. All patients underwent brain MRI within 24-72 h after symptom onset, and participated in a neuropsychological assessment three months post-stroke. We performed hierarchical regression analyses to explore the incremental value of baseline white matter integrity and FC beyond demographic, clinical, and macrostructural information for cognitive outcome. Results: The study cohort comprised 34 patients (mean age: 64 ± 12 years, 35% female). The initial median National Institutes of Health Stroke Scale (NIHSS) score was 10, and significantly improved three months post-stroke to a median NIHSS = 1 (p < .001). Nonetheless, 50% of patients showed cognitive impairment three months post-stroke. FC of the non-lesioned anterior cingulate cortex of the affected hemisphere explained 15% of incremental variance for processing speed (p = .007), and fractional anisotropy of the non-lesioned cingulum of the affected hemisphere explained 13% of incremental variance for cognitive flexibility (p = .033). Conclusions: White matter integrity and functional MRI markers of the DMN in acute stroke explain incremental variance for post-stroke cognitive outcome beyond demographic, clinical, and macrostructural information. Competing Interests: Declaration of competing interest The authors declare no financial or other conflicts of interest that relate to the research covered in this article. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
فهرسة مساهمة: | Keywords: Cognition; Default mode network; Longitudinal; MRI; Stroke |
تواريخ الأحداث: | Date Created: 20240608 Date Completed: 20240710 Latest Revision: 20240710 |
رمز التحديث: | 20240711 |
DOI: | 10.1016/j.jns.2024.123071 |
PMID: | 38850772 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1878-5883 |
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DOI: | 10.1016/j.jns.2024.123071 |