دورية أكاديمية
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The impact of round window reinforcement on middle and inner ear mechanics with air and bone conduction stimulation.

التفاصيل البيبلوغرافية
العنوان: The impact of round window reinforcement on middle and inner ear mechanics with air and bone conduction stimulation.
المؤلفون: Geerardyn A; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium; Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven Belgium., Wils I; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium., Putzeys T; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium; Laboratory of Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Leuven, Belgium., Fierens G; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium; Cochlear Technology Centre, Mechelen, Belgium., Wouters J; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium., Verhaert N; ExpORL, Department of Neurosciences, KU Leuven, Leuven, Belgium; Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven Belgium. Electronic address: nicolas.verhaert@kuleuven.be.
المصدر: Hearing research [Hear Res] 2024 Sep 01; Vol. 450, pp. 109049. Date of Electronic Publication: 2024 May 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7900445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5891 (Electronic) Linking ISSN: 03785955 NLM ISO Abbreviation: Hear Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Round Window, Ear*/physiology , Round Window, Ear*/surgery , Bone Conduction* , Cadaver* , Acoustic Stimulation*, Humans ; Pressure ; Aged ; Ear, Middle/physiology ; Ear, Middle/surgery ; Scala Tympani/surgery ; Scala Tympani/physiology ; Male ; Female ; Scala Vestibuli/surgery ; Scala Vestibuli/physiology ; Scala Vestibuli/physiopathology ; Bone Cements ; Middle Aged ; Biomechanical Phenomena ; Hearing ; Aged, 80 and over ; Ear, Inner/physiology ; Ear, Inner/physiopathology
مستخلص: The round window (RW) membrane plays an important role in normal inner ear mechanics. Occlusion or reinforcement of the RW has been described in the context of congenital anomalies or after cochlear implantation and is applied as a surgical treatment for hyperacusis. Multiple lumped and finite element models predict a low-frequency hearing loss with air conduction of up to 20 dB after RW reinforcement and limited to no effect on hearing with bone conduction stimulation. Experimental verification of these results, however, remains limited. Here, we present an experimental study measuring the impact of RW reinforcement on the middle and inner ear mechanics with air and bone conduction stimulation. In a within-specimen repeated measures design with human cadaveric specimens (n = 6), we compared the intracochlear pressures in scala vestibuli (P SV ) and scala tympani (P ST ) before and after RW reinforcement with soft tissue, cartilage, and bone cement. The differential pressure (P DIFF ) across the basilar membrane - known to be closely related to the hearing sensation - was calculated as the complex difference between P SV and P ST . With air conduction stimulation, both P SV and P ST increased on average up to 22 dB at frequencies below 1500 Hz with larger effect sizes for P ST compared to P SV . The P DIFF , in contrast, decreased up to 11 dB at frequencies between 700 and 800 Hz after reinforcement with bone cement. With bone conduction, the average within-specimen effects were less than 5 dB for either P SV , P ST, or P DIFF . The inter-specimen variability with bone conduction, however, was considerably larger than with air conduction. This experimental study shows that RW reinforcement impacts air conduction stimulation at low frequencies. Bone conduction stimulation seems to be largely unaffected. From a clinical point of view, these results support the hypothesis that delayed loss of air conduction hearing after cochlear implantation could be partially explained by the impact of RW reinforcement.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Bone conduction; Cochlear implant; Inner ear mechanics; Residual hearing; Round window
المشرفين على المادة: 0 (Bone Cements)
تواريخ الأحداث: Date Created: 20240608 Date Completed: 20240719 Latest Revision: 20240719
رمز التحديث: 20240720
DOI: 10.1016/j.heares.2024.109049
PMID: 38850830
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5891
DOI:10.1016/j.heares.2024.109049