دورية أكاديمية

A dynamically cross-linked catechol-grafted chitosan/gelatin hydrogel dressing synergised with photothermal therapy and baicalin reduces wound infection and accelerates wound healing.

التفاصيل البيبلوغرافية
العنوان: A dynamically cross-linked catechol-grafted chitosan/gelatin hydrogel dressing synergised with photothermal therapy and baicalin reduces wound infection and accelerates wound healing.
المؤلفون: Wang Y; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China., Wang J; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Du H; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Zhao Q; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Wang S; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Liu T; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Bi S; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China., Zhang Q; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address: Zhangqingtao@tyut.edu.cn., An M; College of Biomedical Engineer, Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address: Anmeiwen@tyut.edu.cn., Wen S; Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. Electronic address: wensxsx@163.com.
المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Jul; Vol. 273 (Pt 1), pp. 132802. Date of Electronic Publication: 2024 Jun 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
مواضيع طبية MeSH: Chitosan*/chemistry , Flavonoids*/pharmacology , Flavonoids*/chemistry , Wound Healing*/drug effects , Gelatin*/chemistry , Hydrogels*/chemistry , Hydrogels*/pharmacology , Photothermal Therapy*/methods , Catechols*/chemistry , Catechols*/pharmacology , Bandages*, Animals ; Mice ; Wound Infection/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Male
مستخلص: Superior multifunctional hydrogel dressings are of considerable interest in wound healing. In clinical practice, it is useful to investigate hydrogel dressings that offer multifunctional benefits to expedite the process of wound healing. In this study, Catechol-grafted Chitosan, Gelatin, and Fe 3+ as substrates to construct a hydrogel network. The network was dynamically cross-linked to form Ccg@Fe hydrogel substrate. Fe 3 O 4 nanoparticles and baicalin, which possess antimicrobial and anti-inflammatory properties, were loaded onto the substrate to form a photothermal antibacterial composite hydrogel dressing (Ccg@Fe/Bai@Fe 3 O 4 NPs). The Ccg@Fe hydrogel was characterised using Fourier transform infrared spectroscopy (FTIR) and Ultraviolet-visible spectrophotometry (UV-Vis). The morphological, mechanical, and adhesion properties of the hydrogel were determined using scanning electron microscopy (SEM) and a universal testing machine. The hydrogel's swelling, hemostasis, and self-healing properties were also evaluated. Additionally, the study determined the release rate of hydrogel-loaded antimicrobial and anti-inflammatory Baicalin (Ccg@Fe/Bai) and evaluated the photothermal antimicrobial properties of hydrogel-loaded Fe 3 O 4 nanoparticles (Ccg@Fe/Bai@Fe 3 O 4 NPs) through synergistic photothermal therapy (PTT). Histological staining of mice skin wound tissues using Masson and H&E revealed that the Ccg@Fe/Bai@Fe 3 O 4 NPs hydrogel dressing demonstrated potential healing ability with the aid of PTT. The study suggests that this multifunctional hydrogel dressing has great potential for wound healing.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Dynamic cross-link; Photothermal therapy; Self-healing
المشرفين على المادة: 9012-76-4 (Chitosan)
0 (Flavonoids)
347Q89U4M5 (baicalin)
9000-70-8 (Gelatin)
0 (Hydrogels)
0 (Catechols)
LF3AJ089DQ (catechol)
0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20240609 Date Completed: 20240706 Latest Revision: 20240706
رمز التحديث: 20240706
DOI: 10.1016/j.ijbiomac.2024.132802
PMID: 38852721
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0003
DOI:10.1016/j.ijbiomac.2024.132802