دورية أكاديمية
أعرض في EDS

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation.

التفاصيل البيبلوغرافية
العنوان: PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation.
المؤلفون: Park K; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Ju S; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea., Choi H; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea., Gao P; School of Life Sciences, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China., Bang G; Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Cheongju, Republic of Korea., Choi JH; Department of Bio-Chemical Analysis, Korea Basic Science Institute, Cheongju, Republic of Korea., Jang J; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea., Morris AJ; University of Arkansas for Medical Sciences and Central Arkansas Veterans Affairs Healthcare System, Little Rock, AR 72205, USA., Kang BH; School of Life Sciences, State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China., Hsu VW; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Park SY; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 37673, Republic of Korea.
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 25. Date of Electronic Publication: 2024 Jul 25.
نوع المنشور: Journal Article; Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Intracellular transport among organellar compartments occurs in two general ways, by membrane-bound carriers or membrane contacts. Specific circumstances that involve the coordination of these two modes of transport remain to be defined. Studying Coat Protein I (COPI) transport, we find that phosphatidylcholine with short acyl chains (sPC) is delivered through membrane contact from the endoplasmic reticulum (ER) to sites of COPI vesicle formation at the Golgi to support the fission stage. Phosphatidylinositol transfer protein beta (PITPβ) plays a key role in this process, with the elucidation of this role advancing a new understanding of how PITPβ acts, providing a mechanistic understanding of a specific circumstance when vesicular transport requires membrane contact, and contributing to a basic understanding of how transport carriers in a model intracellular pathway are formed.
Competing Interests: Disclosure and competing interest statement The authors declare no competing interests.
معلومات مُعتمدة: IK6 BX006469 United States BX BLRD VA; R37 GM058615 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: COPI vesicle formation; Golgi transport; Lipid transfer; Membrane contact
تواريخ الأحداث: Date Created: 20240610 Latest Revision: 20240805
رمز التحديث: 20240805
مُعرف محوري في PubMed: PMC11160616
DOI: 10.1101/2024.05.27.596058
PMID: 38853868
قاعدة البيانات: MEDLINE
الوصف
تدمد:2692-8205
DOI:10.1101/2024.05.27.596058